Results 141 to 150 of about 565,452 (295)
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Improving STR typing for low template DNA by abasic-site-mediated semi-linear preamplification
Scientific ReportsAlthough progress has been seen for low template DNA (LT-DNA) analysis in the last few years, the obtainment of full short tandem repeat (STR) profiles remains challenging in forensic genetics.
Qiqi Ji +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Quantifying the seismic site amplification characteristics of Adelaide’s regolith [PDF]
, 2018 The historical seismic events have clearly indicated that site amplification has played a principal role in defining the damage to structures founded on the regolith in the city of Adelaide, South Australia.
Setiawan, Bambang
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FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Investigation on Effect of Site Amplification Effect and Source Spectra on Increment of JMA Seismic Intensity [PDF]
, 2019 In this study, I investigated the influence of site amplification effect and source spectra on increment of seismic intensity for the purpose of obtaining basic information for accurately evaluating the increment of seismic intensity(dI).
Hayato, Nishikawa +3 more
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Teknik, 2013 Several methods for evaluating the effect of site specific condition of soil layers against earthquakes are presently available. Site Specific Analysis (SSA) and Horizontal-to-Vertical Spectral Ratio (HVSR) are two methods commonly used for estimating ...
Windu Partono +3 more
doaj
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Evaluation of seismic site amplification factors in Yogyakarta using One-Dimensional site response analysis [PDF]
This study evaluates seismic site amplification in Yogyakarta using one-dimensional (1D) nonlinear site response analysis. Subsurface conditions were characterized using borehole and Standard Penetration Test (SPT) data from four different locations ...
Marasabessy, Muhammad Irfan +2 more
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