Results 101 to 110 of about 5,694,209 (304)

An overview on the seismic microzonation and site effect studies in Central Asia

Annals of Geophysics, 2015
During the past centuries, many cities in Central Asia have suffered significant damages caused by earthquakes. A crucial step towards preparedness for future events, the definition of the optimal engineering designs for civil structures and the ...
Marco Pilz, Tanatkan Abakanov, Kanatbek Abdrakhmatov, Dino Bindi, Tobias Boxberger, Bolot Moldobekov, Sagynbek Orunbaev, Natalya Silacheva, Shahid Ullah, Sheyshenaly Usupaev, Pulat Yasunov, Stefano Parolai   +11 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

V_s30 Derived from Geology: An Attempt in the Province of Quebec, Canada

Geotechnics
The influence of local site conditions is important when assessing the distribution of building damage and seismic risk. The average shear-wave velocity of the top 30 m of soil, Vs30, is one of the most commonly used parameters to characterize site ...
Philippe Rosset, Abdelrahman Elrawy, Surya Nadarajah, Luc Chouinard   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Local seismic response studies in the north-western portion of the August 24th, 2016 Mw 6.0 earthquake affected area. The case of Visso village (central Apennines)

Annals of Geophysics, 2016
In this work, we investigate the possible causes of the differential damaging observed in Visso village (central Apennines, about 28 km north from the August 24th, 2016 Mw 6.0 earthquake epicenter).
Iolanda Gaudiosi, Gianluca Vignaroli, Pietro Sirianni, Silvia Giallini, Federico Mori, Federica Polpetta, Roberto Razzano, Maurizio Simionato, Massimiliano Moscatelli   +8 more
doaj   +1 more source

How about integration: the impact of online activities on store satisfaction and loyalty [PDF]

Although there has been widespread support for the concept of integrating the Internet with other channels, relatively little empirical research has been conducted in this area.
Teerling, Marije L.
core   +1 more source

A flexible multivariate random effects proportional odds model with application to adverse effects during radiation therapy

, 2016
Radiation therapy in patients with head and neck cancer has a toxic effect on mucosa, the soft tissue in and around the mouth. Hence mucositis is a serious common side effect and is a condition characterized by pain and inflammation of the surface of the
Augustin, Nicole, Hanser, Christina, Henke, Michael, Kim, Sung Won, Schumacher, Martin, Uhlig, Annemarie   +5 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Removal of site effects and enhancement of signal using dual projection independent component analysis for pooling multi-site MRI data. [PDF]

Eur J Neurosci, 2023
Hao Y, Xu H, Xia M, Yan C, Zhang Y, Zhou D, Kärkkäinen T, Nickerson LD, Li H, Cong F.   +9 more
europepmc   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source