Results 161 to 170 of about 5,694,209 (304)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Statistical harmonization corrects site effects in functional connectivity measurements from multi-site fMRI data. [PDF]

Hum Brain Mapp, 2018
Yu M, Linn KA, Cook PA, Phillips ML, McInnis M, Fava M, Trivedi MH, Weissman MM, Shinohara RT, Sheline YI.   +9 more
europepmc   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Climate Regimes Override Micro-Site Effects on the Summer Temperature Signal of Scots Pine at Its Northern Distribution Limits. [PDF]

Front Plant Sci, 2018
Lange J, Buras A, Cruz-García R, Gurskaya M, Jalkanen R, Kukarskih V, Seo JW, Wilmking M.   +7 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The chicken hypersensitive site-4 insulator cannot fully shield the murine phosphoglycerate kinase-1 promoter from integration site effects in transgenic mice. [PDF]

3 Biotech, 2019
Farzaneh F, Mirzapoor Z, Jahangirian E, Heidari F, Hashemi E, Rahim-Tayefeh A, Fatemi N, Jamshidizad A, Dashtizad M, Shamsara M.   +9 more
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Brain-age prediction: Systematic evaluation of site effects, and sample age range and size. [PDF]

Hum Brain Mapp
Yu Y, Cui HQ, Haas SS, New F, Sanford N, Yu K, Zhan D, Yang G, Gao JH, Wei D, Qiu J, Banaj N, Boomsma DI, Breier A, Brodaty H, Buckner RL, Buitelaar JK, Cannon DM, Caseras X, Clark VP, Conrod PJ, Crivello F, Crone EA, Dannlowski U, Davey CG, de Haan L, de Zubicaray GI, Di Giorgio A, Fisch L, Fisher SE, Franke B, Glahn DC, Grotegerd D, Gruber O, Gur RE, Gur RC, Hahn T, Harrison BJ, Hatton S, Hickie IB, Hulshoff Pol HE, Jamieson AJ, Jernigan TL, Jiang J, Kalnin AJ, Kang S, Kochan NA, Kraus A, Lagopoulos J, Lazaro L, McDonald BC, McDonald C, McMahon KL, Mwangi B, Piras F, Rodriguez-Cruces R, Royer J, Sachdev PS, Satterthwaite TD, Saykin AJ, Schumann G, Sevaggi P, Smoller JW, Soares JC, Spalletta G, Tamnes CK, Trollor JN, Van't Ent D, Vecchio D, Walter H, Wang Y, Weber B, Wen W, Wierenga LM, Williams SCR, Wu MJ, Zunta-Soares GB, Bernhardt B, Thompson P, Frangou S, Ge R, ENIGMA‐Lifespan Working Group.   +81 more
europepmc   +1 more source