Results 51 to 60 of about 3,153,695 (239)

Breeding dispersal in a resident boreal passerine can lead to short‐ and long‐term fitness benefits

Ecosphere, 2021
Whether an individual disperses or remains site‐faithful between breeding seasons can have important impacts on individual fitness and population dynamics.
Matthew Fuirst, Dan Strickland, D. Ryan Norris   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

In-Water Photo Identification, Site Fidelity, and Seasonal Presence of Harbor Seals (Phoca vitulina richardii) in Burrows Pass, Fidalgo Island, Washington

Oceans
Little is known about the in-water behavior and site fidelity of harbor seals (Phoca vitulina richardii), as most photo-identification (photo-ID) studies are typically conducted while they are hauled-out on land.
Ciera J. Edison, Cindy R. Elliser, Katrina H. White   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Fidelity Charitable Trustees' Initiative 2019 Impact Report [PDF]

, 2019
The Fidelity Charitable Trustees' Initiative is a direct grantmaking program of Fidelity Charitable separate from its donor-advised fund program. Last fiscal year, the Trustees' Initiative made 23 grants totaling $6.4 million to strengthen the resilience,

core   +2 more sources

A Variable-Fidelity Modeling Method for Aero-Loads Prediction [PDF]

, 2008
A Variable-Fidelity Modeling (VFM) method has been developed as an efficient and accurate aerodynamic data modeling strategy. In this approach, a set of CFD methods with varying degrees of fidelity and computational expense is exercised to reduce the ...
Han, Zhong-Hua, Hain, Rainer, Görtz, Stefan   +2 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Cultural traditions across a migratory network shape the genetic structure of southern right whales around Australia and New Zealand [PDF]

, 2015
ELC was supported by the AMMC and a Newton Fellowship from the Royal Society and RH in part by a Sitka Sound Science Centre Scientist in Residency Fellowship. OEG acknowledges support from the MASTS pooling initiative (The Marine Alliance for Science and
Carroll, Emma Louise, Gröcke, D. R., J. Bannister (3245850), Harcourt, Robert, R. Alderman (3245853), Alderman, Rachael, Gröcke, Darren, O. E. Gaggiotti (3245862), E. L. Carroll (12840311), Baker, C. Scott, Gaggiotti, O.E., Patenaude, Nathalie, Watson, M., Baker, C. S., M. Watson (3245868), N. Patenaude (3245865), Gröcke, D.R., Gaggiotti, Oscar Eduardo, D. R. Gröcke (3245856), Gaggiotti, O. E., Patenaude, N., Harcourt, R., Watson, Mandy, C. S. Baker (12840314), Baker, C.S., Bannister, John, Alderman, R., Bannister, J., Carroll, E.L., R. Harcourt (3245859), Carroll, E. L.   +30 more
core   +1 more source