Results 51 to 60 of about 421,026 (281)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

In-Water Photo Identification, Site Fidelity, and Seasonal Presence of Harbor Seals (Phoca vitulina richardii) in Burrows Pass, Fidalgo Island, Washington

Oceans
Little is known about the in-water behavior and site fidelity of harbor seals (Phoca vitulina richardii), as most photo-identification (photo-ID) studies are typically conducted while they are hauled-out on land.
Ciera J. Edison, Cindy R. Elliser, Katrina H. White   +2 more
doaj   +1 more source

Guiana dolphins, Sotalia guianensis (Cetacea: Delphinidae), in the Paranaguá Estuarine Complex: insights on the use of area based on the photo-identification technique

Zoologia (Curitiba), 2010
The aim of the present study was to provide a preliminary description of habitat use by Guiana dolphins, Sotalia guianensis (Van Bénéden, 1864) in the Paranaguá Estuarine Complex (PEC), state of Paraná, Brazil.
Marcos C. de O. Santos, Júlia E. de F. Oshima, Eduardo dos S. Pacífico, Ednilson da Silva   +3 more
doaj   +1 more source

Photographic Capture-Recapture Analysis Reveals a Large Population of Indo-Pacific Bottlenose Dolphins (Tursiops aduncus) With Low Site Fidelity off the North West Cape, Western Australia

Frontiers in Marine Science, 2020
Little is known about the ecology of Indo-Pacific bottlenose dolphins (Tursiops aduncus) inhabiting the coastal waters of tropical north-western Australia.
Rebecca Haughey, Tim Hunt, Daniella Hanf, Daniella Hanf, Robert William Rankin, Guido J. Parra   +5 more
doaj   +1 more source

Ground state fidelity in bond-alternative Ising chains with Dzyaloshinskii-Moriya interactions

, 2011
A systematic analysis is performed for quantum phase transitions in a bond-alternative one-dimensional Ising model with a Dzyaloshinskii-Moriya (DM) interaction by using the fidelity of ground state wave functions based on the infinite matrix product ...
Bing-Quan Hu, Bo Li, Calabrese P, Cardy J, Dai Y-W, Hong-Lei Wang, Sachdev S, Sam Young Cho, Zheludev A, Zhou H-Q, Zhou H-Q, Zhou H-Q   +11 more
core   +1 more source

Coordination of tRNA Synthetase Active Sites for Chemical Fidelity [PDF]

Journal of Biological Chemistry, 2012
Statistical proteomes that are naturally occurring can result from mechanisms involving aminoacyl-tRNA synthetases (aaRSs) with inactivated hydrolytic editing active sites. In one case, Mycoplasma mobile leucyl-tRNA synthetase (LeuRS) is uniquely missing its entire amino acid editing domain, called CP1, which is otherwise present in all known LeuRSs ...
Michal T, Boniecki, Susan A, Martinis
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Breeding dispersal in a resident boreal passerine can lead to short‐ and long‐term fitness benefits

Ecosphere, 2021
Whether an individual disperses or remains site‐faithful between breeding seasons can have important impacts on individual fitness and population dynamics.
Matthew Fuirst, Dan Strickland, D. Ryan Norris   +2 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source