Results 111 to 120 of about 2,082,962 (313)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

The effect in sheep of physical form on the sites of digestion of a dried lucerne diet [PDF]

, 1972
J. F. Coelho Da Silva, Robert C. Seeley, D. J. Thomsont, D. E. Beever, D. G. Armstkong   +4 more
openalex   +1 more source

Data from Breast Cancer Risk–Associated SNPs in the <i>mTOR</i> Promoter Form <i>De Novo</i> KLF5- and ZEB1-Binding Sites that Influence the Cellular Response to Paclitaxel

, 2023
Qiuchen Chen, Xiaolan Deng, Xiao Hu, Shu Guan, Miao He, Yilin Wang, Binbin Wei, Jing Zhang, Haishan Zhao, Weifan Yao, Feng Jin, Yong Liu, Jianjun Chen, Olufunmilayo I. Olapade, Huizhe Wu, Minjie Wei   +15 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Reduction potentials and their pH dependence in site‐directed‐mutant forms of azurin from Pseudomonas aeruginosa [PDF]

, 1993
Torbjörn Pascher, Göran Karlsson, Margareta Nordling, Bo G. Malmström, Tore Vänngård   +4 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Remaining Sites Verification Package for the 1607-F1 Sanitary Sewer System (124-F-1) and the 100-F-26:8 (1607-F1) Sanitary Sewer Pipelines Waste Sites, Waste Site Reclassification Form 2005-004

, 2008
L. M. Dittmer
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Methylation of the CpG sites in the myotonic dystrophy locus does not correlate with CTG expansion size or with the congenital form of the disease

, 2010
Claudia Spits, Sara Seneca, Pierre Hilven, I. Liebærs, Karen Sermon   +4 more
openalex   +2 more sources

Cover Feature: Single‐Site Ruthenium Pincer Complex Knitted into Porous Organic Polymers for Dehydrogenation of Formic Acid (ChemSusChem 20/2018) [PDF]

, 2018
Xinbo Wang, Eleanor Pei Ling Ang, Chao Guan, Qinggang Zhang, Wenting Wu, Pengxin Liu, Nanfeng Zheng, Daliang Zhang, Sergei Lopatin, Zhiping Lai, Kuo‐Wei Huang   +10 more
openalex   +1 more source