A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Frontiers in Environmental ScienceIntroductionSince its reform and opening up, China’s new urbanization strategy, which provides institutional support for the optimization of the spatial form of tourism towns, has made remarkable progress and demonstrated great potential.
Tengzhe Long +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Truncated forms of the insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor encompassing the IGF-II binding site: characterization of a point mutation that abolishes IGF-II binding. [PDF]
, 1996 Farideh Garmroudi +4 more
openalex +1 more source
Divergent regulation of auxin responsive genes in root-knot and cyst nematodes feeding sites formed in Arabidopsis [PDF]
, 2023 Patricia Abril‐Urías +11 more
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Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Symmetric bimetallic active sites Prussian blue catalysts for photo-reforming biomass to formic acid [PDF]
Junming Shi +6 more
openalex +1 more source
Delineation of the third antigenic site of lysozyme by application of a novel ‘surface-simulation’ synthetic approach directly linking the conformationally adjacent residues forming the site [PDF]
, 1976 C L Lee, M. Zouhair Atassi
openalex +1 more source