Results 181 to 190 of about 2,082,962 (313)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Fracture healing: cellular mechanisms and impact of parathyroid hormone and its analogs. [PDF]

Front Endocrinol (Lausanne)
Bikle D.
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Measuring What Matters in Trial Operations: Development and Validation of the Clinical Trial Site Performance Measure. [PDF]

J Clin Med
Bozzetti M, Lo Cascio A, Napolitano D, Orgiana N, Mora V, Fiorini S, Petrucci G, Resente F, Baroni I, Caruso R, Guberti M, Performance Working Goup.   +11 more
europepmc   +1 more source

Plexus: an investigation of site in relation to form

, 2014

openalex   +1 more source

Study protocol: a randomized controlled trial evaluating the effectiveness of a novel in-situ forming bone graft for lateral bone augmentation in compromised alveolar sites [PDF]

Nasim Safdarian, Amir Jalal Abbasi, Amir Reza Rokn, Ahmad Reza Shamshiri, Hamid Mobedi   +4 more
openalex   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Derivatization of Bufadienolides at Carbon-3 of the Steroid Core and Their Consequences for the Interaction with Na⁺,K⁺-ATPase. [PDF]

Int J Mol Sci
Ladefoged LK, Schiøtt B, Fedosova NU.
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

The terminal Ediacaran Tongshan Lagerstätte from South China. [PDF]

Nat Commun
Hou JB, Wang XD, Hou ZS, Ramezani J, Tang Q, Shen SZ.   +5 more
europepmc   +1 more source