Results 181 to 190 of about 2,188,564 (214)

Internet-based vestibular rehabilitation versus written instructions after acute vertigo: A randomised controlled trial. [PDF]

PLoS One
Surano S, Lindell E, Mathé J, Davidsson H, Tomanovic T, Bjurman M, Faergemann E, Ledin T, Rostmark A, Grip H, Öhberg F, Granåsen G, Salzer J.   +12 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A Highly Conserved Glycine in a Hotspot for Neurological Disease Mutations in Na⁺,K⁺-ATPase Is Critical to Na⁺ and K⁺ Occlusion. [PDF]

Biomolecules
Toustrup-Jensen MS, Holm R, Andersen JP, Vilsen B.   +3 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Incessant Focal Atrial Tachycardia Originating From the Right Inferior Pulmonary Vein With Extremely Short Cycle Length and Variable Exit Block. [PDF]

Case Rep Cardiol
Hayashi H, Sekita G, Minamino T.
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Occlusogram-Guided Interdisciplinary Planning in Implant Dentistry and Orthodontics for Oral Rehabilitation. [PDF]

Cureus
Gameiro GH, Andrade AS.
europepmc   +1 more source