Results 231 to 240 of about 2,082,962 (313)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A unique gating mechanism revealed by the cryo-EM structure of monomeric ATP9A flippase. [PDF]

J Biol Chem
Abe K, Marimuthu P, Qian Y, Gopalasingam CC, Gerle C, Shigematsu H, Tanaka K, Khandelia H.   +7 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

From Binding to Catalysis: Emergence of a Rudimentary Enzyme Conferring Intrinsic Antibiotic Resistance. [PDF]

Mol Biol Evol
Lemay-St-Denis C, Cellier-Goetghebeur S, St-Aubin M, Ide K, Copp JN, Tsuda S, Ben-Tal N, Kolodny R, Pelletier JN.   +8 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Unveiling of phosphodiesterase-5 hot residues binding to xanthine derivatives for erectile dysfunction therapy: A computational drug repurposing approach. [PDF]

PLoS One
Elzupir AO, Almahmoud SAJ.
europepmc   +1 more source

Structural mechanisms for cold-adapted activity of phosphoenolpyruvate carboxykinase. [PDF]

Protein Sci
McLeod MJ, Yazdani S, Barwell SAE, Holyoak T.   +3 more
europepmc   +1 more source

Modeling loess collapsibility using oedometer tests for foundation and pile settlement prediction. [PDF]

Sci Rep
Long Z, Ye S, Hao Y, He L, Zhu Y, Mu J, Li X.   +6 more
europepmc   +1 more source

A structural roadmap for the formation of the coronavirus nsp3/nsp4 double membrane vesicle pore and its implications for polyprotein processing and replication/transcription. [PDF]

J Virol
Perry JK, Itskanov S, Bilello JP, Lansdon EB.   +3 more
europepmc   +1 more source