Results 231 to 240 of about 1,531,150 (267)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Observing intersubunit dynamics in single yeast ribosomes. [PDF]

Nucleic Acids Res
Das A, Grove AK, Ivanov AV, Wakabayashi H, Ermolenko DN.   +4 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Clinical and economic impact of incisional negative pressure wound therapy in breast surgery: meta-analysis. [PDF]

Br J Surg
Kollatos C, Sackey H, Pantiora E, Vorburger D, Rocco N, Öhrn C, Valachis A, Eriksson S, Karakatsanis A.   +8 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A homozygous splice-site variant in SAMHD1 shows variable expressivity of Aicardi-Goutières syndrome type 5: a case report and literature review. [PDF]

Front Pediatr
Yousaf H, Zonash Z, Manzoor J, Ali A, Khalid LB, Zafar G, Ali S, Toft M, Fatima A, Iqbal Z.   +9 more
europepmc   +1 more source

Endoscopic grasping forceps rescue retrieval of a migrated biliary stent using a sheath-assisted technique. [PDF]

Endoscopy
Urakabe K, Kato A, Adachi A, Kito Y, Toyohara T, Hori Y, Yoshida M.   +6 more
europepmc   +1 more source

Validation of the SMART-REACH model after stroke and the effect of colchicine by atherosclerotic cardiovascular disease risk category: a secondary analysis of the CONVINCE randomised clinical trial. [PDF]

Eur Stroke J
Maes L, Verschuere C, Walsh C, Weimar C, Purroy F, Price C, Fonseca C, Hill MD, Jatuzis D, Kõrv J, Kruuse C, Mikulik R, Nederkoorn P, Czlonkowska A, Fischer U, McCormick M, Castellanos M, Baptista M, Marto JP, Thavanesan K, Williams DJ, Kelly P, Lemmens R, CONVINCE investigators .   +23 more
europepmc   +1 more source