Results 81 to 90 of about 2,410,081 (311)

Site-Specific Drug-Releasing Polypeptide Nanocarriers Based on Dual-pH Response for Enhanced Therapeutic Efficacy against Drug-Resistant Tumors

, 2015
To enhance effective drug accumulation in drug-resistant tumors, a site-specific drug-releasing polypeptide system (PEG-Phis/Pasp-DOX/CA4) was exploited in response to tumor extracellular and intracellular pH.
Zhang, Xin, Yaqiong Dong, Yang, Jun, Tang, Suoqin, Suoqin Tang, Liu, Hongmei, Hongmei Liu, Jun Yang, Tianyou Wang, Zhang, Jinchao, Wang, Tianyou, Jinchao Zhang, Dong, Yaqiong   +12 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

SAVANNAH RIVER SITE CAPABILITIES FOR CONDUCTING INGESTION PATHWAY CONSEQUENCE ASSESSMENTS FOR EMERGENCY RESPONSE [PDF]

, 2007
Potential airborne releases of radioactivity from facilities operated for the U. S. Department of Energy at the Savannah River Site could pose significant consequences to the public through the ingestion pathway.
Hunter, C
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Incorporating site response analysis and associated uncertainties into the seismic hazard assessment of nuclear facilities

, 2013
textThe development of a site-specific seismic hazard curve for a soil site requires the incorporation of site effects into the hazard calculation through the use of a site-specific amplification function.
Pehlivan, Menzer
core  

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Site amplification model for use in ground motion prediction equations [PDF]

, 2013
textThe characteristics of earthquake shaking are affected by the local site conditions. The effects of the local soil conditions are often quantified via an amplification factor (AF), which is defined as the ratio of the ground motion at the soil ...
Navidi, Sara
core  

Neural Network-Based Prediction of Amplification Factors for Nonlinear Soil Behaviour: Insights into Site Proxies

Applied Sciences
The identification of the most pertinent site parameters to classify soils in terms of their amplification of seismic ground motions is still of prime interest to earthquake engineering and codes.
Ahmed Boudghene Stambouli, Lotfi Guizani
doaj   +1 more source

Microtremor Recording Surveys to Study the Effects of Seasonally Frozen Soil on Site Response. [PDF]

Sensors (Basel), 2023
Chen S, Lei J, Li Y.
europepmc   +1 more source