Results 191 to 200 of about 9,966,235 (337)

Meta-unstable mRNAs in activated CD8⁺ T cells are defined by interlinked AU-rich elements and m⁶A mRNA methylation. [PDF]

Nat Commun
Gameiro PA, Foskolou IP, Butt YA, Martens AAM, Kuret Hodnik K, Ruiz de Los Mozos I, Zandhuis ND, Hozjan Ž, Kot VM, Faraway R, Vermeulen M, Wolkers MC, Johnson RS, Ule J.   +13 more
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Automatic detection of potential mosquito breeding sites from aerial images acquired by unmanned aerial vehicles

, 2021
Daniel Trevisan Bravo, Gustavo Araújo Lima, Wonder Alexandre Luz Alves, Vitor Pessoa Colombo, Luc Djogbénou, Sergio Vicente Denser Pamboukian, Cristiano Capellani Quaresma, Sidnei Alves de Araújo   +7 more
openalex   +2 more sources

Evaluating genetic-based disease prediction approaches through simulation. [PDF]

Hum Genet
Shpak M, Parfitt E, Mahmoudiandehkordi S, Maadooliat M, Schrodi SJ.   +4 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Efficient and stable catalytic hydrolysis of perfluorocarbon enabled by SO₂-mediated proton supply. [PDF]

Nat Commun
Zhang H, Luo T, Chen Y, Wang X, Mariani E, Liu K, Fu J, Liu C, Liu H, Lin Z, Chai L, Coote ML, Cortés E, Liu M.   +13 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Influence of drill mud on the microbial communities of sandstone rocks and well fluids at the Ketzin pilot site for CO2 storage

, 2017
Linda Pellizzari, Tobias Lienen, Monika Kasina, Hilke Würdemann   +3 more
openalex   +2 more sources

A Prospective Comparison of 18F-FDG PET/CT and CT as Diagnostic Tools to Identify the Primary Tumor Site in Patients with Extracervical Carcinoma of Unknown Primary Site [PDF]

, 2012
Anne Kirstine Hundahl Møller, Annika Loft, Anne Kiil Berthelsen, Karen Damgaard Pedersen, Jesper Graff, Charlotte Birk Christensen, Junia C. Costa, Lene Theil Skovgaard, Katharina Perell, Bodil Laub Petersen, Gedske Daugaard   +10 more
openalex   +1 more source

Pepsin Digestion for Proteomic Studies of the Human Hair Shaft. [PDF]

Rapid Commun Mass Spectrom
Yee DH, Mukhtarov R, Sharma AD, Lin C, Sun B.   +4 more
europepmc   +1 more source