Results 191 to 200 of about 12,868,149 (415)

STUDIES ON HYDRALAZINE; EVIDENCE FOR A PERIPHERAL SITE OF ACTION 1 [PDF]

open access: bronze, 1954
Albert J. Stunkard   +3 more
openalex   +1 more source

Removing the “I” Factor: Examining the Barriers to Career Progression for Black Women [PDF]

open access: yes
This research aims to advance theory concerning career progression barriers for Black women. It introduces and advances critical race theory and theories of identity blindness and consciousness as important mechanisms that impact the Black women’s career
O’Toole, Jay, Sites, Anthony
core   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

Playing it safe? a study of the regulation of outdoor play for children and young people in residential care [PDF]

open access: yes, 2007
The aim of the research was to describe and explain the barriers to, and opportunities for, outdoor play and recreation that exist in residential child care services.
McGuinness, L.   +2 more
core  

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

A different way to look at things : the development of consultancy in a residential service for children and young people [PDF]

open access: yes, 2005
The support of consultancy and the tasks associated with consultation are considered to play a vital role in the development of good practice in residential care and in safeguarding children and young people.
Kendrick, Andrew   +1 more
core  

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

open access: yesMolecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric   +11 more
wiley   +1 more source

Holding safely : guidance for residential child care practitioners and managers about physically restraining children and young people [PDF]

open access: yes, 2005
Residential child care is intensive and at times very diffificult work. Staff in residential childcare, therefore, need training, advice, supervision and support in undertaking this demanding work, since they are often doing the hardest of social care ...
Davidson, Jennifer   +4 more
core  

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

open access: yesMolecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen   +17 more
wiley   +1 more source

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