Results 211 to 220 of about 12,868,149 (415)

Surveillance, big data and democracy: lessons for Australia from the US and UK [PDF]

open access: yes, 2014
This article argues that current laws are ill-equipped to deal with the multifaceted threats to individual privacy by governments, corporations and our own need to participate in the information society.
Beatrix van Dissel   +2 more
core  

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

open access: yesMolecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren   +4 more
wiley   +1 more source

Prevalence rate of white spot syndrome virus (WSSV) in farmed white leg shrimp (Litopenaeus vannamei) in Bushehr province

open access: yes‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2009
We surveyed presence of white spot syndrome virus (WSSV) in farmed white leg shrimp in Bushehr province with assumed a prevalence of 2% of virus in target population. Hence, 468 samples were collected in two separate phases from May to October 2006.
A. Ghajari; A. Seidi; K. Absalan fard; H. Yavari; M. Kosari
doaj  

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

Estrutura de informação para sites municipais: reunindo cidadania e ergonomia = Information structure for e-government: citizen and ergonomic criteria

open access: yesActa Scientiarum: Technology, 2005
Especificamente no setor público, a Internet tem procurado aproximar os cidadãos dos serviços públicos. Assim, há novas exigências para o setor público, como o fornecimento de serviços via Internet e a transparência das informações. Entretanto, não basta
Tania Fatima Calvi Tait   +5 more
doaj  

A path to purposive formalism: interpreting Chapter III for judicial independence and impartiality [PDF]

open access: yes, 2012
This paper queries which method of interpreting Chapter III of Australia\u27s Constitution can best achieve the independence and impartiality of the federal judicature.AbstractThe interpretation of the separation of federal judicial power derived from ...
Rebecca Welsh
core  

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

open access: yesMolecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan   +6 more
wiley   +1 more source

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