Results 231 to 240 of about 9,966,235 (337)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

US Department of Defense–Funded Fate and Transport Research on Per- and Polyfluoroalkyl Substances at Aqueous Film–Forming Foam–Impacted Sites

, 2020
Richard H. Anderson, Timothy A. Thompson, Hans F. Stroo, Andrea Leeson   +3 more
openalex   +1 more source

Trans-Tissue Effects of Hippocampus- and Blood-Derived DNA Methylation Risk Scores on Bipolar Disorder Diagnosis. [PDF]

Bipolar Disord
Ohi K, Fujikane D, Takai K, Kuramitsu A, Muto Y, Sugiyama S, Shioiri T.   +6 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Two mutations in the beta-globin polyadenylylation signal reveal extended transcripts and new RNA polyadenylylation sites.

, 1992
Deborah Rund, Carol E. Dowling, Khamis Najjar, E. A. Rachmilewitz, H H Kazazian, A Oppenheim   +5 more
openalex   +2 more sources

Metastasis-directed radiotherapy for oligometastatic urothelial carcinoma of the bladder and upper tract. [PDF]

Bladder Cancer
Carriere P, Alhalabi O, Gao J, Shah A, Goswami S, Campbell M, Lin R, Mayo L, Mohamad O, Hoffman K, Mok H, Lozano C, Kamat A, Navai N, Bree K, Lee B, Guo C, Rooney M, Tang C, Choi S, Hassanzadeh C.   +20 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Prospective Randomized Study to Assess the Efficacy of Site and Rate of Atrial Pacing on Long-Term Progression of Atrial Fibrillation in Sick Sinus Syndrome

, 2013
Chu‐Pak Lau, Tachapong Ngarmukos, Chun‐Chieh Wang, Jing-feng Wang, Haruhiko Abe, Chi‐Woon Kong, Reginald Liew, Dong‐Gu Shin, Luigi Padeletti, You‐Ho Kim, Razali Omar, Kreingkrai Jirarojanakorn, Yoon-Nyun Kim, Mien‐Cheng Chen, Charn Sriratanasathavorn, Muhammad Munawar, Ruth Kam, Jan-Yow Chen, Yong-Keun Cho, Yi‐Gang Li, Shu-Lin Wu, Christophe Bailleul, Hung‐Fat Tse   +22 more
openalex   +2 more sources

Using Serially Collected Specimens to Investigate the Potential Population Genetic Consequences of Reported Declines in Eastern Woodland Salamanders. [PDF]

Ecol Evol
O'Connell KA, Muletz-Wolz CR, Wynn A, Lips KR, Ellison A, Zamudio KR, Bell RC.   +6 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source