Results 251 to 260 of about 9,966,235 (337)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Do current biomass equations for Alnus glutinosa and Betula pubescens misestimate carbon stocks at peatland sites? [PDF]

Carbon Balance Manag
Gercken H, Möller M, Mendez Cartin AL, Bielefeldt J, Wolfram E, Wellbrock N, Gärtner J, Oertel C.   +7 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Implications of Binding Mode and Active Site Flexibility for Inhibitor Potency against the Salicylate Synthase from Mycobacterium tuberculosis

, 2012
Gamma Chi, Alexandra Manos‐Turvey, P. D. T. O’Connor, Jodie M. Johnston, Genevieve L. Evans, Edward N. Baker, Richard J. Payne, J. Shaun Lott, Esther M. M. Bulloch   +8 more
openalex   +1 more source

Evaluating the Use of Environmental DNA as a Method to Determine Occupancy and Distribution of Coeur d'Alene Salamanders in Montana. [PDF]

Ecol Evol
Coltrane JA, Ritter T, Specht H, Mason DH, Anderson A, Franklin TW.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bright Sparks of Single-Atom and Nano-Islands in Catalysis: Breaking Activity-Stability Trade-Off. [PDF]

Nanomicro Lett
Liu X, Chen S, Luo S, Li B, Wang J, Zhang G, Zhu Y, Zou J.   +7 more
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

High prevalence of colonization with Staphylococcus aureus clone USA300 at multiple body sites among sexually transmitted disease clinic patients: an unrecognized reservoir

, 2012
Benjamin A. Miko, Anne‐Catrin Uhlemann, Amanda Gelman, Caroline J. Lee, Cory Hafer, Sean B. Sullivan, Qiuhu Shi, Maureen Miller, Jonathan M. Zenilman, Franklin D. Lowy   +9 more
openalex   +2 more sources

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source