Results 151 to 160 of about 15,435,920 (254)

On Mechanistic Interpretation of Cross-Sectional Mediation in Sitting Time and Urinary Leakage [Letter]. [PDF]

Int J Womens Health
Xiong Y, Li Z.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Screen Time, Sitting Time, Physical Activity, and Multisite Musculoskeletal Pain in University Students: Implications for Preventive Healthcare. [PDF]

Healthcare (Basel)
Bayraktar EE, Mohammadzadeh M.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Correction: Daily sitting time and past-year falls in Japanese adults: an exploratory cross-sectional analysis. [PDF]

Front Sports Act Living
Ukawa S, Kato Y, Lee Y, Sugiyama M, Saito H, Ohara K, Mori K.   +6 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Occupational class differences in daily sitting time among young and early midlife public sector employees-a follow-up study. [PDF]

Eur J Public Health
Päivärinne V, Kekäläinen E, Pietiläinen O, Valkonen J, Lahti J, Lahelma E, Kouvonen A, Rahkonen O, Lallukka T.   +8 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Creating a culture of prevention in occupational safety and health practice: perceived body discomfort in two sitting positions

, 2018
Prolonged sitting is one of the factors for back discomfort. Sitting in the same position for long periods of time is worse. This experimental based study was conducted to achieve three objectives.
Part Time Noor Husna binti Mohamad Zayadi
core  

Sleep Quality and Adherence to the Mediterranean Diet in Male Young Adults: An Exploratory Study Among Amateur Soccer Players, Physically Active Individuals, and Individuals with High Sitting Time. [PDF]

Sports (Basel)
Festino E, Papale O, Di Rocco F, Zema S, De Maio M, Dos Santos Amorim PR, Foster C, Amato A, Proia P, Cortis C, Fusco A.   +10 more
europepmc   +1 more source