Results 141 to 150 of about 14,817,059 (300)

Correlation between Physical Activity Time Reported by the IPAQ and Accelerometer in Syrian Adults

Epidemiology, Biostatistics and Public Health
Background: The accelerometer and self-report questionnaires have been recommended as efficient methods to measure physical activity (PA). The aim of this work is to investigate issues associated with PA assessment using the ActiGraph WGT3X-BT (AG ...
Mahfouz Al-Bachir, Husam Ahmad
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Under the Clouds of War

, 1972
Consists of film clips of World War II events, including Mussolini\u27s invasion of Ethiopia and Hitler\u27s march into Austria.
Time-Life Video
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Physically active learning and school-based physical activity interventions in reducing sedentary time among secondary school students: literature review

Pedagogy of Health
Background and Study Aim. Sedentary behavior has become a growing concern among secondary school students in contemporary educational settings. Learning activities, screen use, and classroom routines often require students to remain seated for prolonged ...
Trisnar Adi Prabowo, Mar'atul Afifah, Asyidika Vito Indarto, Zakwan Yumna Dhuha Pahlavi, Achmad Zakaria, Febriansyah Dwi Cahyo   +5 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Desk-based occupational sitting patterns: Weight-related health outcomes

, 2013
Background: Prolonged, uninterrupted sitting time is associated with poor health outcomes. As most sitting time occurs at work, accurate, objective measurement of occupational sitting patterns is required to fully understand its effects on employee ...
Gilson, Nicholas D, Gilson, Nicholas D., Peeters, Geeske M E E, Ryde, Gemma, Peeters, G.M.E.E., Brown, Helen E., Brown, Helen E, Brown, Wendy J, Brown, Wendy J., Ryde, Gemma C.   +9 more
core   +1 more source