Results 121 to 130 of about 14,817,059 (300)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Project Energise: Using participatory approaches and real time computer prompts to reduce occupational sitting and increase work time physical activity in office workers

, 2015
Objectives  This efficacy study assessed the added impact real time computer prompts had on a participatory approach to reduce occupational sedentary exposure and increase physical activity.  Design  Quasi-experimental.  Methods 57 ...
Pavey, Toby, Gilson, Nicholas D, Gilson, Nicholas D., Ryde, Gemma, Pavey, Toby G., Gilson, Nicholas, Pavey, T., Straker, Leon, Brown, Wendy J., Brown, W., Ng, N., Brown, Wendy, Ng, Norman, Ryde, G., Gilson, N., Pavey, Toby G, Brown, Wendy J, Ryde, Gemma C.   +17 more
core   +1 more source

Sitting Time, Physical Activity, and Risk of Mortality in Adults

Journal of the American College of Cardiology, 2019
It is unclear what level of moderate to vigorous intensity physical activity (MVPA) offsets the health risks of sitting.The purpose of this study was to examine the joint and stratified associations of sitting and MVPA with all-cause and cardiovascular disease (CVD) mortality, and to estimate the theoretical effect of replacing sitting time with ...
Stamatakis, E, Gale, J, Bauman, A, Ekelund, U, Hamer, M, Ding, D   +5 more
openaire   +4 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Time spent sitting during and outside working hours in bus drivers: A pilot study [PDF]

, 2015
This cross-sectional pilot study objectively measured sedentary and non-sedentary time in a sample of bus drivers from the East Midlands, United Kingdom. Participants wore an activPAL3 inclinometer for 7days and completed a daily diary.
Biddle, Stuart J.H., Varela-Mato, Veronica, Thomas Yates (171609), Biddle, Stuart J. H., Veronica Varela-Mato (3204960), Yates, Thomas, Clemes, Stacy A., Veronica Varela-Mato (7237928), Thomas E. Yates (7237088), Stacy A. Clemes (3135465), Varela-Mato, V, David J. Stensel (7236716), Stensel, DJ, David Stensel (1257075), Stensel, David J, Clemes, Stacy A, Stensel, David J., Stuart J.H. Biddle (7238342), Clemes, SA, Biddle, Stuart, Yates, T, Stacy Clemes (1256949), Stuart J. H. Biddle (7665737)   +22 more
core   +1 more source

Who is at risk of chronic disease? Associations between risk profiles of physical activity, sitting and cardio‐metabolic disease in Australian adults

Australian and New Zealand Journal of Public Health, 2017
Objective: To examine the associations of physical activity (PA) and sitting time (sit) with cardio‐metabolic diseases. Methods: Cross‐sectional data from the Australian National Nutrition and Physical Activity Survey 2011–2012 (n=9,435) were used to ...
Lina Engelen, Joanne Gale, Josephine Y. Chau, Louise L. Hardy, Martin Mackey, Nathan Johnson, Debra Shirley, Adrian Bauman   +7 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

The Cardiovascular Consequences of Excess Sitting Time [PDF]

The Journal of Clinical Hypertension, 2015
Steven G, Chrysant, George S, Chrysant
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Sitting-time and 9-year all-cause mortality in older women

, 2015
Background Studies of mid-aged adults provide evidence of a relationship between sitting-time and all-cause mortality, but evidence in older adults is limited.
Pavey, Toby, Pavey, Toby G., Peeters, GMEE (Geeske), Brown, Wendy J., Peeters, Geeske   +4 more
core   +1 more source