Results 101 to 110 of about 15,435,920 (254)

Reducing sitting time after stroke: a phase II safety and feasibility randomized controlled trial [PDF]

, 2016
Objective: To test the safety, feasibility, and effectiveness of reducing sitting time in stroke ...
Kramer, S., Bernhardt, J., Healy, G.N., Borkoles, E, Healy, GN, Olds, T, Healy, Genevieve N., Borkoles, Erika, Bernhardt, Julie, English, C, Coates, A., Kramer, Sharon, Borkoles, E., Parfitt, G, Healy, G. N., Parfitt, G., Kramer, S, Parfitt, Gaynor, Olds, T., Bernhardt, J, Coates, Alison, English, Coralie, English, C., Olds, Tim, Coates, A   +24 more
core   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Desk-based occupational sitting patterns: Weight-related health outcomes

, 2013
Background: Prolonged, uninterrupted sitting time is associated with poor health outcomes. As most sitting time occurs at work, accurate, objective measurement of occupational sitting patterns is required to fully understand its effects on employee ...
Gilson, Nicholas D, Gilson, Nicholas D., Peeters, Geeske M E E, Ryde, Gemma, Peeters, G.M.E.E., Brown, Helen E., Brown, Helen E, Brown, Wendy J, Brown, Wendy J., Ryde, Gemma C.   +9 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Cross-sectional associations between sitting time and several aspects of mental health in Belgian adults

, 2015
Background: Sedentary behavior (including sitting) is negatively associated with physical health, independent from physical activity (PA). Knowledge on the associations with mental health is less elaborated.
De Bourdeaudhuij, Ilse, De Cocker, Katrien, Asztalos, Melinda, Cardon, Greet   +3 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Can reducing sitting time in the university setting improve the cardiometabolic health of college students?

, 2018
Karrie M Butler,1 Joyce S Ramos,2 Christina A Buchanan,1 Lance C Dalleck1,2 1Department of Recreation, Exercise, and Sport Science, Western State Colorado University, Gunnison, CO, USA; 2SHAPE Research Centre, Exercise Science and Clinical Exercise ...
Butler KM, Ramos JS, Dalleck LC, Buchanan CA   +3 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source