Results 111 to 120 of about 15,435,920 (254)

Regression plots for cardio-metabolic risk factors for leisure-time sitting, occupational sitting and overall sitting time.

, 2013
A Waist circumference (n=2414), B BMI (n=2412), C Body fat (n=2408), D Total cholesterol (n=2402), E HDL cholesterol (n=2269), F LDL cholesterol (n=2251), G Triglycerides (n=2269), H Insulin (n=2268), I Hemoglobin A1c (n=2273), J Plasma glucose (n=2269).
Rikke K. Jacobsen (442210), Mette Aadahl (437783), Torben Jørgensen (154033), Allan Linneberg (139773), Madina Saidj (442209)   +4 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Who is at risk of chronic disease? Associations between risk profiles of physical activity, sitting and cardio‐metabolic disease in Australian adults

Australian and New Zealand Journal of Public Health, 2017
Objective: To examine the associations of physical activity (PA) and sitting time (sit) with cardio‐metabolic diseases. Methods: Cross‐sectional data from the Australian National Nutrition and Physical Activity Survey 2011–2012 (n=9,435) were used to ...
Lina Engelen, Joanne Gale, Josephine Y. Chau, Louise L. Hardy, Martin Mackey, Nathan Johnson, Debra Shirley, Adrian Bauman   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Associations between sitting time and weight in young adult Australian women

, 2010
Sedentary behaviour may be a contributor to weight gain in today's young adult women, who are gaining weight faster than women in their mothers' generation.
Van Uffelen, Jannique G. Z, De Cocker, Katrien A., De Cocker, Katrien A, van Uffelen, Jannique, De Cocker, Katrien, Brown, Wendy J., Wendy J. Brown, Jannique G.Z. van Uffelen, van Uffelen, Jannique G. Z., Brown, Wendy, Katrien A. De Cocker, De Cocker, Katrien. A., Brown, Wendy J, van Uffelen, Jannique GZ   +13 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Letter from Mrs. John Sitting Crow to Congressman Burdick Regarding Fort Berthold Claims, February 25, 1954

, 1954
This letter, dated February 25 1954, from Mrs. John Sitting Crow of New Town North Dakota to United States (US) Representative Usher Burdick refers to the Three Affiliated Tribes of the Fort Berthold Reservation\u27s claims before the US Court of Claims.
Sitting Crow,
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Intervening to reduce workplace sitting time: How and when do changes to sitting time occur?

, 2022
Objective To investigate how and when changes in workplace sitting time occurred following a workplace intervention to inform evaluation of intervention success.
G N Healy (13347138), E G Eakin (13347120), S F M Chastin (13384482), S G Trost (13421637), E A H Winkler (13347114), S K Stephens (13385508), D W Dunstan (13474171)   +6 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source