Results 111 to 120 of about 14,817,059 (300)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Acute and Prolonged Impact of Knee-Flexion Angle on Popliteal Hemodynamics and Flow-Mediated Dilation Responses to Sitting

, 2022
The purpose of this study was to determine the impact of prolonged sitting (~2.5 h) at knee-flexion angles of 0°, 45°, and 90° on popliteal blood flow (PBF) and endothelial-dependent, flow-mediated dilation (FMD).
Wu, Yanlin
core  

Sitting time, physical activity and sleep by work type and pattern – the Australian Longitudinal Study on Women’s Health [PDF]

, 2017
Data from the Australian Longitudinal Study on Women’s Health were used to examine how work was associated with time spent sleeping, sitting and in physical activity (PA), in working women. Young (31–36 years; 2009) and mid-aged (59–64 years; 2010) women
Duncan, Mitch J., Kolbe-Alexander, Tracy L., Clark, Bronwyn K., Brown, Wendy, Bronwyn Clark, Tracy Kolbe-Alexander, Mitch Duncan, Wendy Brown   +7 more
core   +1 more source

Differential cross-sectional associations of work- and leisure-time sitting, with cardiorespiratory and muscular fitness among working adults

Scandinavian Journal of Work, Environment & Health, 2014
OBJECTIVES: Sedentary behavior is increasingly recognized as a risk factor for cardiovascular and metabolic morbidity and mortality. Recent studies suggest that sitting during work and leisure time may affect markers of cardiometabolic health ...
Madina Saidj, Torben Jørgensen, Rikke K Jacobsen, Allan Linneberg, Mette Aadahl   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Are we chained to our desks? Describing desk-based sitting using a novel measure of occupational sitting

, 2014
Background: Prolonged occupational sitting is related to poor health outcomes. Detailed data on sitting time at desks are required to understand and effectively influence occupational sitting habits. Methods: Full-time office employees were recruited (n =
Brown, Helen Elizabeth, Gilson, Nicholas David, Gilson, Nicholas D, Brown, Wendy, Ryde, Gemma, Ryde, Gemma Cathrine, Brown, Helen E, Brown, Wendy J, Brown, Wendy J., Ryde, Gemma C.   +9 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Office workers’ experiences of attempts to reduce sitting-time: An exploratory, mixed- methods uncontrolled intervention pilot study [PDF]

, 2019
Background: Office workers typically sit for most of the workday, which has been linked to physical and mental ill- health and premature death. This mixed-methods study sought to identify barriers and facilitators to reducing sitting and increasing ...
Biddle, SJH, Dewitt, S, Buckley, John P, Biddle, Stuart J. H., Gardner, B, Buckley, JP, Louise Mansfield (49270), Mansfield, L, Mansfield, Louise, Lee Smith (59284), Jennifer Hall (3489161), Smith, L, Gardner, Benjamin David, Buckley, John P., Stephen Dewitt (4622656), Smith, Lee, John Buckley (4586650), Dewitt, Stephen, Stuart Biddle (3458192), Gardner, Benjamin, Buckley, John, Biddle, Stuart J. H, Hall, Jennifer, Benjamin Gardner (3484646), Hall, J, Dewitt, Stephen Harrison, Biddle, Stuart Jh   +26 more
core   +1 more source