Results 51 to 60 of about 17,769 (248)
Grasping the Situation: analyzing how situational dynamics shape agency
Frontiers in PsychologyDespite the intimacy between the situation and our agency, “situation” remains an ambiguous concept in theory. Even within the context of situated theories of cognition and agency that take the organism-environment system as central in their ...
Thijs Heijmeskamp, Thijs Heijmeskamp
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Activités, 2004 The paper aims at presenting professional didactics as a theoretical framework which enables a) to take into account the various components of professional competence (work process knowledge, schemes of action, « quality » of perception and motor action,
Janine Rogalski
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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Networks as a case of distributed cognition
Akademisk Kvarter, 2017 Within the development of recent theories of epistemologies, notions of situated, embodied, extended and distributed cognition has been objects of study.
Bo Allesøe
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
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FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
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FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
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BASES PARA UM REFERENCIAL TEÓRICO SOBRE O FENÔMENO DA COGNIÇÃO
Ensaio Pesquisa em Educação em CiênciasResumo: Apresentamos um referencial teórico para investigar a sala de aula, que articulamos a partir das seguintes matrizes teórico-metodológicas: cognição situada, etnometodologia, fundamentos biológicos da cognição, cognição distribuída e fenomenologia.
Adelson Fernandes Moreira, Oto Borges
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FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
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Texto Livre: Linguagem e Tecnologia, 2014 One goal of STIS (Interdisciplinary Theoretical Seminars of Semiotec ) is to discuss at a conference on a theoretical topic of one of the areas of expertise and research of Texto Livre Group: Semiotics and Technology aimed an interdisciplinary audience ...
Elizabeth Guzzo de Almeida
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