Results 21 to 30 of about 447,435 (164)

Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4.

PLoS Pathogens, 2022
Both SIV and SHIV are powerful tools for evaluating antibody-mediated prevention and treatment of HIV-1. However, owing to a lack of rhesus-derived SIV broadly neutralizing antibodies (bnAbs), testing of bnAbs for HIV-1 prevention or treatment has thus ...
Hugh C Welles, Hannah A D King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A Schramm, Nicole A Doria-Rose, Adrienne E Swanstrom, James A Hoxie, Celia LaBranche, David C Montefiori, Daniel C Douek, Peter D Kwong, John R Mascola, Mario Roederer, Rosemarie D Mason   +22 more
doaj   +1 more source

Genetic adaptations to SIV across chimpanzee populations.

PLoS Genetics, 2022
Central and eastern chimpanzees are infected with Simian Immunodeficiency Virus (SIV) in the wild, typically without developing acute immunodeficiency. Yet the recent zoonotic transmission of chimpanzee SIV to humans, which were naïve to the virus, gave ...
Harvinder Pawar, Harrison J Ostridge, Joshua M Schmidt, Aida M Andrés   +3 more
doaj   +1 more source

Liver Bacterial Dysbiosis With Non-Tuberculosis Mycobacteria Occurs in SIV-Infected Macaques and Persists During Antiretroviral Therapy

Frontiers in Immunology, 2022
Liver disease is a significant contributor to morbidity and mortality in HIV-infected individuals, even during successful viral suppression with combination antiretroviral therapy (cART).
Bridget S. Fisher, Katherine A. Fancher, Andrew T. Gustin, Cole Fisher, Matthew P. Wood, Michael Gale, Benjamin J. Burwitz, Jeremy Smedley, Nichole R. Klatt, Nina Derby, Donald L. Sodora   +10 more
doaj   +1 more source

Bioinformatics Study of the Interaction between Melittin Protein and P24 Protein in HIV and SIV Viruses

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: P24 is one of the important components of retroviruses capsid. Several studies have shown the inhibitory effect of melittin protein on the function of AIDS virus. The aim of this study was to evaluate the effect of this protein on
Zahra Hasanshahi, Behzad Dehghani, Tayebeh Hashempour, Javad Moayedi   +3 more
doaj  

A Novel IDO1/NE Dual Inhibitor, IMM-H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression. [PDF]

Adv Sci (Weinh)
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Zhou Y, Zhao X, Pan X, Ma Z, Cui H, Wen H, Wang P, Liao X, Qin K, Wang Y, Sheng L, Zhang S.   +11 more
europepmc   +2 more sources

Urinary Neopterin Indicates Early Infection and Disease Progression: Model Studies with Simian and Human Immunodeficiency Viruses in Macaques

Pteridines, 2002
The value of urinary neopterin as a predictive marker for disease progression in SIV- and HIV-2-infected rhesus (Macaca mulatta) and cynomolgus macaques (Macaca fascicularis) was assessed by comparing pre- with postinfection data. Before infection stable
Stahl-Hennig Christiane, Fendrich Claudia, Lüke Wolfgang, Widner Bernhard, Hunsmann Gerhard, Fuchs Dietmar   +5 more
doaj   +1 more source

SIV Evolutionary Dynamics in Cynomolgus Macaques during SIV-Mycobacterium tuberculosis Co-Infection

Viruses, 2021
Co-infection with Mycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV) is a worldwide public health concern, leading to worse clinical outcomes caused by both pathogens.
Kaho H. Tisthammer, Christopher Kline, Tara Rutledge, Collin R. Diedrich, Sergio Ita, Philana Ling Lin, Zandrea Ambrose, Pleuni S. Pennings   +7 more
doaj   +1 more source

Therapeutic conserved elements (CE) DNA vaccine induces strong T-cell responses against highly conserved viral sequences during simian-human immunodeficiency virus infection

Human Vaccines & Immunotherapeutics, 2018
HIV-specific T-cell responses play a key role in controlling HIV infection, and therapeutic vaccines for HIV that aim to improve viral control will likely need to improve on the T-cell responses induced by infection.
Paul Munson, Yi Liu, Debra Bratt, James T. Fuller, Xintao Hu, George N. Pavlakis, Barbara K. Felber, James I. Mullins, Deborah Heydenburg Fuller   +8 more
doaj   +1 more source

Long Term Delta-9-tetrahydrocannabinol Administration Inhibits Proinflammatory Responses in Minor Salivary Glands of Chronically Simian Immunodeficieny Virus Infected Rhesus Macaques

Viruses, 2020
HIV/SIV-associated oral mucosal disease/dysfunction (HAOMD) (gingivitis/periodontitis/salivary adenitis) represents a major comorbidity affecting HIV patients on anti-retroviral therapy. Using a systems biology approach, we investigated molecular changes
Xavier Alvarez, Karol Sestak, Siddappa N. Byrareddy, Mahesh Mohan   +3 more
doaj   +1 more source

Prevalence and Predictors of Seasonal Influenza Vaccine Uptake in Saudi Arabia Post COVID-19: A Web-Based Online Cross-Sectional Study

Vaccines, 2023
In the fall of 2022, the number of influenza-like illnesses (ILIs) and severe acute respiratory infections (SARIs) in Saudi Arabia had significantly increased compared with the corresponding period in previous years.
Saeed Mastour Alshahrani, Yousef Zahrani
doaj   +1 more source