Results 71 to 80 of about 92,071 (290)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Wide-Speed Range Operation of PM Vernier Machines Using Wye and Wye-Delta Winding Configurations

IEEE Access, 2020
This paper proposes two permanent magnet vernier machines (PMVM) operation modes, for wide-speed and high efficiency operation. In mode-1, the machine operates as a conventional PMVM with a wye connected stator winding mode. In mode-2, the machine stator
Arsalan Arif, Noman Baloch, Muhammad Ayub, Byung-Il Kwon   +3 more
doaj   +1 more source

BPS States of Exceptional Non-Critical Strings [PDF]

, 1996
We study the BPS states of non-critical strings which arise for zero size instantons of exceptional groups. This is accomplished by using F-theory and M-theory duals and by employing mirror symmetry to compute the degeneracy of membranes wrapped around 2-
Klemm, A., Mayr, P., Vafa, C.
core   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Variation polarity control strategy for six-phase SRM with different winding topologies

Advances in Mechanical Engineering
This paper proposes a novel polarity variation control strategy for six-phase switched reluctance motors (SRMs). The magnetic pole distribution characteristics under three-phase conduction are analyzed, revealing that an NSN pole arrangement yields ...
Wei Qiao, Shouyi Han, Xiaodong Sun, Rui Yang   +3 more
doaj   +1 more source

Mathematical Modeling and Electromagnetic Characteristics Analysis of a Six-Phase Distributed Single-Winding BPMSM with 12 Slots and 2 Poles

Applied Sciences
This work focuses on small bearingless permanent magnet synchronous motors (BPMSMs). In order to enhance its torque control stiffness and improve the stability of its torque and magnetic levitation force dynamic waveforms, a novel six-phase distributed ...
Wenshao Bu, Jiangdi Li, Yongfang Lu
doaj   +1 more source

Investigating the Effect of Winding Structures in Dynamic Wireless Power Transmission in Electric Vehicle Applications [PDF]

Iranica Journal of Energy and Environment
In recent decades, problems such as air pollution and the reduction of fossil fuel resources led to the development of electric vehicles. Wireless power transmission is an efficient and reliable way to charge fixed and mobile electric vehicles.
M. Rafinejad, A. Ghayebloo
doaj   +1 more source