Results 91 to 100 of about 4,558,823 (350)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Six Sigma Driven Enterprise Model Transformation

International Journal of Engineering Business Management, 2009
Enterprise architecture methods provide a structured system to understand enterprise activities. However, existing enterprise modelling methodologies take static views of the enterprise and do not naturally lead to a path of improvement during enterprise
Raymond Vella, Sekhar Chattopadhyay, John P.T. Mo   +2 more
doaj   +2 more sources

Enhancing Pharma Manufacturing Efficiency: Integrating Lean Six Sigma and Fuzzy FMEA for Waste Reduction

Spektrum Industri: Jurnal Ilmiah Pengetahuan dan Penerapan Teknik Industri
In pharmaceutical manufacturing, inefficiencies such as waiting times, excessive material usage, and packaging defects can significantly impact productivity and quality.
Rindi Kusumawardani, Adiyodha Ayudha Widyatmoko   +1 more
doaj   +1 more source

Agile Six Sigma in Healthcare: Case Study at Santobono Pediatric Hospital

International Journal of Environmental Research and Public Health, 2020
Healthcare is one of the most complex systems to manage. In recent years, the control of processes and the modelling of public administrations have been considered some of the main areas of interest in management.
G. Improta, G. Guizzi, C. Ricciardi, Vincenzo Giordano, A. M. Ponsiglione, G. Converso, M. Triassi   +6 more
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Usulan Perbaikan Kualitas Penggulungan Benang Nilon Dengan Menggunakan Metode Six Sigma di PT. XYZ

Jurnal Energi Dan Manufaktur, 2016
Abstrak: PT. XYZ merupakan perusahaan yang bergerak dibidang textil yang memproduksi benang jahit. Perusahaan selalu berusaha meningkatkan kualitas produknya dalam penanganan produk yang cacat yang terjadi pada proses produksi karena jumlah cacat yang ...
I Wayan Sukania, Iphov Kumala Sriwana, Edwin Suryajaya   +2 more
doaj  

The Process to Estimate Economical Benefits of Six Sigma Projects

Kvalita Inovácia Prosperita, 2013
This paper seeks to define the process for the continuous evaluation of the financial benefits during Six Sigma project life time. The financial criteria are critical success factors of a Six Sigma project.
Jan Kosina
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

ANALISIS KECACATAN PRODUK AIR MINUM DALAM KEMASAN (AMDK) SEBAGAI UPAYA PERBAIKAN KUALITAS DENGAN METODE DMAIC

Spektrum Industri: Jurnal Ilmiah Pengetahuan dan Penerapan Teknik Industri, 2014
Produsen air minum dalam kemasan (AMDK) mengalami masalah kualitas yaitu dengan terdapatnya produk-produk cacat pada setiap produksi yang belum mencapai zero defect, terutama pada lini produksi kemasan gelas ukuran 240 ml yang paling banyak mengalami ...
Heri Wibowo, Emy Khikmawati
doaj