Results 71 to 80 of about 725,296 (298)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Six Sigma Driven Enterprise Model Transformation

International Journal of Engineering Business Management, 2009
Enterprise architecture methods provide a structured system to understand enterprise activities. However, existing enterprise modelling methodologies take static views of the enterprise and do not naturally lead to a path of improvement during enterprise
Raymond Vella, Sekhar Chattopadhyay, John P.T. Mo   +2 more
doaj   +2 more sources

Enhancing Pharma Manufacturing Efficiency: Integrating Lean Six Sigma and Fuzzy FMEA for Waste Reduction

Spektrum Industri: Jurnal Ilmiah Pengetahuan dan Penerapan Teknik Industri
In pharmaceutical manufacturing, inefficiencies such as waiting times, excessive material usage, and packaging defects can significantly impact productivity and quality.
Rindi Kusumawardani, Adiyodha Ayudha Widyatmoko   +1 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Usulan Perbaikan Kualitas Penggulungan Benang Nilon Dengan Menggunakan Metode Six Sigma di PT. XYZ

Jurnal Energi Dan Manufaktur, 2016
Abstrak: PT. XYZ merupakan perusahaan yang bergerak dibidang textil yang memproduksi benang jahit. Perusahaan selalu berusaha meningkatkan kualitas produknya dalam penanganan produk yang cacat yang terjadi pada proses produksi karena jumlah cacat yang ...
I Wayan Sukania, Iphov Kumala Sriwana, Edwin Suryajaya   +2 more
doaj  

A theoretical framework for exploring the effect of the Six Sigma management activities on corporate competitiveness

, 2011
Six Sigma has long been used as an effective way to restructure a company’s management process. While there are abundant case study literatures on Six Sigma, a theoretical framework that can logically advance the previous work into a higher level is ...
Lee, Kun-Chang, Choi, Bong, Li, Honglei
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ACHIEVING COMPETITIVE ADVANTAGE THROUGH THE LEAN SIX SIGMA MODEL [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie
In light of the intricate and evolving market landscape induced by globalisation and the health crisis, companies must swiftly respond to the actions of their competitors.
ANDRISAN GABRIELA NICOLETA, MODREANU ANDRA   +1 more
doaj  

The Process to Estimate Economical Benefits of Six Sigma Projects

Kvalita Inovácia Prosperita, 2013
This paper seeks to define the process for the continuous evaluation of the financial benefits during Six Sigma project life time. The financial criteria are critical success factors of a Six Sigma project.
Jan Kosina
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source