Results 61 to 70 of about 3,611,450 (267)

Enhancing Pharma Manufacturing Efficiency: Integrating Lean Six Sigma and Fuzzy FMEA for Waste Reduction

open access: yesSpektrum Industri: Jurnal Ilmiah Pengetahuan dan Penerapan Teknik Industri
In pharmaceutical manufacturing, inefficiencies such as waiting times, excessive material usage, and packaging defects can significantly impact productivity and quality.
Rindi Kusumawardani   +1 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Six Sigma Driven Enterprise Model Transformation

open access: yesInternational Journal of Engineering Business Management, 2009
Enterprise architecture methods provide a structured system to understand enterprise activities. However, existing enterprise modelling methodologies take static views of the enterprise and do not naturally lead to a path of improvement during enterprise
Raymond Vella   +2 more
doaj   +2 more sources

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

A theoretical framework for exploring the effect of the Six Sigma management activities on corporate competitiveness [PDF]

open access: yes, 2011
Six Sigma has long been used as an effective way to restructure a company’s management process. While there are abundant case study literatures on Six Sigma, a theoretical framework that can logically advance the previous work into a higher level is ...
Lee, Kun-Chang, Choi, Bong, Li, Honglei
core  

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

ACHIEVING COMPETITIVE ADVANTAGE THROUGH THE LEAN SIX SIGMA MODEL [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie
In light of the intricate and evolving market landscape induced by globalisation and the health crisis, companies must swiftly respond to the actions of their competitors.
ANDRISAN GABRIELA NICOLETA   +1 more
doaj  

The Process to Estimate Economical Benefits of Six Sigma Projects

open access: yesKvalita Inovácia Prosperita, 2013
This paper seeks to define the process for the continuous evaluation of the financial benefits during Six Sigma project life time. The financial criteria are critical success factors of a Six Sigma project.
Jan Kosina
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Six Sigma vs. Design for Six Sigma: selection of the requisite Six Sigma approach using multi-criteria decision analysis: innovation report [PDF]

open access: yes
The literature suggests that organisations which have adopted Six Sigma have realised that upon achieving a Five Sigma level the only way to surpass this is to redesign the process(es) by means of Design for Six Sigma (DFSS). For others, the selection of
Bañuelas, Ricardo
core  

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