Results 51 to 60 of about 725,296 (298)

Six Sigma vs Lean : some perspectives from leading academics and practitioners

, 2011
The purpose of this paper is to present the fundamental and critical differences between two of the most powerful methodologies in a process excellence initiative in any organisation.
Antony, Jiju, Jiju Antony
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Lean Six Sigma as an enabler for healthcare operational excellence in COVID-19

, 2021
Purpose -This paper aims to present the results of a qualitative research interview study on the utilization and importance of Lean Six Sigma methods in the Healthcare sector in COVID-19 and in pandemics in general.
Antony, Jiju, Jiju, Antony, McDermott, Olivia, Dr, McDermott, Olivia   +3 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Barriers of six sigma in healthcare organizations [PDF]

Management Science Letters, 2018
Six Sigma approach is based on decreasing defects and variations in the products and processes, and it provides important benefits to healthcare organizations.
Serkan Deniz , Mesut Çimen
doaj   +1 more source

Improve safety, health, and environmental protection through the introduction of Six Sigma [PDF]

, 2003
Plan BThe primary objective of this study was to evaluate the impact of implementation of a Six Sigma program on a company’s safety, health, and environmental protection performance.
Kaliher, Thomas L.
core  

Determining the essential characetristics of Six Sigma Black Belts

, 2007
A Six Sigma Black Belt (SSBB) plays the role of a full-time team leader responsible for implementing process improvement projects using the Six Sigma methodology (Define-Measure-Analyse-Improve-Control) within the business to drive up customer ...
Antony, Jiju, Douglas, Alex, Antony, Frenie Jiju   +2 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Peningkatan kualitas dan efisiensi pada proses produksi dunnage menggunakan metode lean six sigma (Studi kasus di PT. XYZ)

Teknika, 2020
PT. XYZ merupakan industri manufaktur dalam bidang pembuatan dunnage. Dalam proses produksinya, masih ditemukan pemborosan yang mengakibatkan cacatan pada produk dunnage.
Asep Ridwan, Faula Arina, Ardi Permana
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source