Results 41 to 50 of about 8,025,456 (269)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Six Sigma Analysis of Vitamin D Measurement Using External Quality Assessment Program
Korean Journal of Clinical Laboratory Science, 2020 Standardization of vitamin analysis continues around the world, and much effort has been made to improve the accuracy of the results. This study analyzed the sigma metrics of the vitamin D test using the external quality assessment (EQA) program.
Myungsuk Ji
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
THE IMPLEMENTATION OF SIX SIGMA IN MANUFACTURING ORGANIZATIONS: MOTIVATIONS AND RESULTS ACHIEVED
Faces: Revista de Administração, 2005 The competitive context forces organizations to choose improvement tools that yield maximum efficiency from their operations. There are many articles about Six Sigma in the technical literature but academic research is not so abundant. This research aims
Antônio Domingos Padula +1 more
doaj
Penerapan Six Sigma Untuk Penyelenggaraan Ujian Akhir Nasional SMU Di Lima Wilayah DKI Jakarta
Jurnal Pendidikan dan Kebudayaan, 2010 This paper discusses the results of research on the application of Six Sigma at the junior national exam in Jakarta. This research was conducted on the implementation of the national exam in academic year 2007/2008 Jakarta using survey questionnaire ...
Prayekti --, Hanafi --
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Six Sigma vs Lean : some perspectives from leading academics and practitioners [PDF]
, 2011 The purpose of this paper is to present the fundamental and critical differences between two of the most powerful methodologies in a process excellence initiative in any organisation.
Antony, Jiju
core +4 more sources
Gestão & Produção, 2007 A utilização do Seis Sigma e das técnicas associadas ao programa tem possibilitado resultados que merecem uma avaliação mais detalhada, pois existem relativamente poucos dados publicados sobre a aplicação do Seis Sigma no país.
João Marcos Andrietta +1 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source