Results 201 to 210 of about 25,853 (250)

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

open access: yesAdvanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie   +12 more
wiley   +1 more source

AEGIS: Individual-based modeling of life history evolution. [PDF]

open access: yesPLoS Comput Biol
Bagic M   +3 more
europepmc   +1 more source

STUDIES ON THE BIOLOGY OF THE SEA URCHIN:Ⅱ. Size at First Maturity and Sexuality of Two Sea Urchins, Strongylocentrotus nudus and S. intermedius

open access: yesSTUDIES ON THE BIOLOGY OF THE SEA URCHIN:Ⅱ. Size at First Maturity and Sexuality of Two Sea Urchins, Strongylocentrotus nudus and S. intermedius
openaire  

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

open access: yesAdvanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña   +7 more
wiley   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

open access: yesAdvanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li   +7 more
wiley   +1 more source

Inter- and intraspecific morphometric divergences in a Seychelles endemic gecko genus. [PDF]

open access: yesBMC Ecol Evol
Roesch MA   +10 more
europepmc   +1 more source

Histological and Macromolecular Characterization of Folliculogenesis in Loggerhead Sea Turtles (<i>Caretta caretta</i>): Novel Insights into the Onset of Puberty. [PDF]

open access: yesInt J Mol Sci
Di Renzo L   +13 more
europepmc   +1 more source

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