Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie +12 more
wiley +1 more source
AEGIS: Individual-based modeling of life history evolution. [PDF]
Bagic M +3 more
europepmc +1 more source
openaire
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña +7 more
wiley +1 more source
Unsafe sexual practice and associated factors among adolescents in secondary schools in Gambella town, Ethiopia: a health belief model. [PDF]
Frissa T +3 more
europepmc +1 more source
NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li +7 more
wiley +1 more source
Inter- and intraspecific morphometric divergences in a Seychelles endemic gecko genus. [PDF]
Roesch MA +10 more
europepmc +1 more source
Biological aspects and population dynamics of the European pilchard Sardina pilchardus (Walbaum, 1792) in the southeastern Mediterranean waters. [PDF]
Badreldin M +3 more
europepmc +1 more source
Seasonal Variation in Selected Reproductive Characteristics of Male Common Pheasants (<i>Phasianus colchicus</i>) Throughout the Annual Cycle. [PDF]
Nawłatyna P +3 more
europepmc +1 more source
Histological and Macromolecular Characterization of Folliculogenesis in Loggerhead Sea Turtles (<i>Caretta caretta</i>): Novel Insights into the Onset of Puberty. [PDF]
Di Renzo L +13 more
europepmc +1 more source

