Results 271 to 280 of about 372,530 (379)

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Optimizing Messenger RNA Analysis Using Ultra-Wide Pore Size Exclusion Chromatography Columns. [PDF]

Int J Mol Sci
D'Atri V, Lardeux H, Goyon A, Imiołek M, Fekete S, Lauber M, Zhang K, Guillarme D.   +7 more
europepmc   +1 more source

Formation of Condition‐Dependent Alpha‐Synuclein Fibril Strain in Artificial Cerebrospinal Fluid

Advanced Science, EarlyView.
α‐synuclein aggregation in artificial cerebrospinal fluid (aCSF) leads to a distinct conformation with an electron density pocket motif found in aggregates from PD and MSA patients. Such fibrils has low stability outside the reaction conditions, hinting about the influence of cerebrospinal fluid components not only on the formation, but also on the ...
Rūta Sniečkutė, Darius Šulskis, Arūnė Jocytė, Urtė Venclovaitė, Rimgailė Tamulytė, Mantas Žiaunys, Vytautas Smirnovas, Andrius Sakalauskas   +7 more
wiley   +1 more source

Size and conformation of Ficoll as determined by size-exclusion chromatography followed by multiangle light scattering

, 2009
William H. Fissell, Christina L. Hofmann, Ross Smith, Michelle H. Chen   +3 more
openalex   +2 more sources

Chromatography of anticancer drugs [PDF]

, 2013
Cserháti, Tibor, Szőgyi, Mária
core  

Choice of size-exclusion chromatography column affects recovery, purity, and miRNA cargo analysis of extracellular vesicles from human plasma. [PDF]

Extracell Vesicles Circ Nucl Acids
Bracht JWP, Los M, van der Pol E, Verkuijlen SAWM, van Eijndhoven MAJ, Pegtel DM, Nieuwland R.   +6 more
europepmc   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Analyzing Insulin Samples by Size-Exclusion Chromatography: A Column Degradation Study

, 2015
Brandon M. Teska, Amit Kumar, John F. Carpenter, Michael F. Wempe   +3 more
openalex   +2 more sources

A Robust and Efficient Method to Purify DNA-Scaffolded Nanostructures by Gravity-Driven Size Exclusion Chromatography. [PDF]

Langmuir
Ebrahimimojarad A, Wang Z, Zhang Q, Shah A, Brenner JS, Fu J.   +5 more
europepmc   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source