Results 111 to 120 of about 5,002,207 (261)

Infant heart transplantation with extremely oversized donor heart: is the donor-recipient size matching too conservative? [PDF]

ESC Heart Fail, 2023
Wen S, Zhou Y, Qiao W, Wang Y, Zhang J, Dong N.   +5 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

New Results on Graph Matching from Degree-Preserving Growth

Mathematics
The recently introduced model in S. R. Kharel et al.’s study [Degree-preserving network growth. Nature Physics 2022, 18, 100–106] uses matchings to insert new vertices of prescribed degrees into the current graph of an ever-growing graph sequence.
Péter L. Erdős, Shubha R. Kharel, Tamás Róbert Mezei, Zoltán Toroczkai   +3 more
doaj   +1 more source

Indexed donor cardiac output for improved size matching in heart transplantation: A United Network for Organ Sharing database analysis. [PDF]

JTCVS Open, 2023
Pasrija C, Kon ZN, Shah A, Holmes SD, Rozenberg KS, Joseph S, Griffith BP.   +6 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Algorithmic Approach of Majority Voting With Agents’ Inclusiveness for Facility Resource Matching

IEEE Access
In a two-sided matching with preferences, an agent has preferences over the agents from the other side. In a head-to-head election between any two matchings, the agent votes for the matching with a better allocation in the pairing based on its preference.
Peash Ranjan Saha, Salimur Choudhury, Kai Salomaa   +2 more
doaj   +1 more source

Evidence supporting total cardiac volumes instead of weight for transplant size-matching. [PDF]

J Heart Lung Transplant, 2021
Szugye NA, Morales DLS, Lorts A, Zafar F, Moore RA.   +4 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Matching in thin labour markets: panel data evidence from Finland, 1991-2002 [PDF]

The matching function that postulates a relationship between the flow of new matches and stock of job seekers and vacancies has attracted considerable attention, both theoretical and empirical during the last decade.
Jaakko Pehkonen, Aki Kangasharju, Sari Pekkala   +2 more
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