Results 111 to 120 of about 13,693,867 (238)

Evaluating Size-Specific Dose Estimate (SSDE) as an Estimate of Organ Doses Derived from Monte Carlo Simulations of CT Exams [PDF]

, 2019
INTRODUCTIONIn 2011, the American Association of Physicist in Medicine (AAPM) devised the Size-Specific Dose Estimate (SSDE) quantity in Report 204. SSDE is a dose metric that adjusts the commonly-reported CTDIvol metric to account for patient size. SSDE
Hardy, Anthony James
core   +1 more source

Investigating the Effect of Patient-Related Factors on Computed Tomography Radiation Dose Using Regression and Correlation Analysis

Applied Sciences
Computed tomography (CT) is a widely utilized diagnostic imaging modality in medicine. However, the potential risks associated with radiation exposure necessitate investigating CT exams to minimize unnecessary radiation. The objective of this study is to
Mohammad AlShurbaji, Sara El Haout, Akchunya Chanchal, Salam Dhou, Entesar Dalah   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Size-specific dose estimation in pediatric computed tomography: From dose characterization to individualized optimization

World Journal of Radiology
Pediatric computed tomography (CT) is clinically indispensable for emergency care, neurologic disorders, thoracoabdominal diseases, trauma assessment, and oncologic diagnosis and follow-up. However, children should not be regarded as small adults. They are actively growing and developing, and organs or tissues such as the hematopoietic system, thyroid,
openaire   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Diagnostic CT organ dose estimation in whole-body PET/CT examinations–comparison of a patient-specific monte carlo approach and a computational phantom-based CT dosimetry tool

EJNMMI Physics
Background Studies evaluating the impact of advances in CT dosimetry tools on CT organ dose estimations are often limited to a comparison with TLD measurements in anthropomorphic phantoms or a comparison of different dosimetry tools using computational ...
Gwenny Verfaillie, Yves D’Asseler, Klaus Bacher   +2 more
doaj   +1 more source

Estimation of Radiation Dose in CT Chest and Abdomen Examinations Using Size-Specific Dose Estimates

OALib, 2023
Abdulrahman Amer, Wafaa Ahmed, Abdulaziz Hussein, Aman Mehta, Ahmed Khalif, Mohammed Abdullah   +5 more
openaire   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Optimal designs for dose finding studies [PDF]

Identifying the "right" dose is one of the most critical and difficult steps in the clinical development process of any medicinal drug. Its importance cannot be understated: selecting too high a dose can result in unacceptable toxicity and associated ...
Dette, Holger, Bretz, Frank
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