Results 61 to 70 of about 34,933 (276)

OP0143 EFFICACY AND SAFETY OF DAZODALIBEP (VIB4920/HZN4920) IN SUBJECTS WITH SJÖGREN'S SYNDROME: A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PROOF OF CONCEPT STUDY [PDF]

, 2023
E. W. St, Clair, Wang Li, Ilias Alevizos, William A. Rees, Alan N. Baer, Wan‐Fai Ng, Ghaith Noaiseh, Chiara Baldini   +8 more
openalex   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

The role of microRNAs in the pathogenesis of autoimmune diseases [PDF]

, 2018
K
Chen, Ji-Qing, Papp, Gábor, Szodoray, Péter, Zeher, Margit   +3 more
core   +1 more source

POS1459 THE WEIGHT OF ANTI-LA/SSB ANTIBODIES IN RO/SSA-POSITIVE PATIENTS WITH A NEWLY DIAGNOSED SJÖGREN'S SYNDROME: A PHENOTYPE CHARACTERIZED BY A MORE SEVERE MAJOR AND MINOR GLANDULAR INVOLVEMENT AND A HIGHER BIOLOGICAL ACTIVITY [PDF]

, 2023
Silvia Fonzetti, G. Fulvio, G. La Rocca, I. C. Navarro García, G. Governato, Rossana Izzetti, V. Donati, F. Ferro, Marta Mosca, Chiara Baldini   +9 more
openalex   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Quantitative Assessment of Salivary Gland Parenchymal Vascularization Using Power Doppler Ultrasound and Superb Microvascular Imaging: A Potential Tool in the Diagnosis of Sjögren"s Syndrome

Balkan Medical Journal, 2020
Background: Primary Sjögren’s syndrome is a chronic inflammatory autoimmune disease. Minor salivary gland biopsy is the gold standard for the diagnosis of primary Sjögren’s syndrome.
Fethi Emre Ustabaşıoğlu, Selçuk Korkmaz, Ufuk İlgen, Serdar Solak, Osman Kula, Sezin Turan, Hakan Emmüngil   +6 more
doaj   +1 more source

Sjögren's syndrome sufferers have increased oral yeast levels despite regular dental care [PDF]

, 2008
Aim: To investigate the prevalence and quantity of oral yeasts and their association with oral candidiasis in Sjögren's syndrome (SS) patients receiving regular dental care. Materials and methods: Yeasts in oral rinse and full-mouth supra-gingival plaque
Cheung, BPK, Leung, KCM, Leung, WK, McMillan, AS   +3 more
core   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source

Severe dental caries as the first presenting clinical feature in primary sjÖgren's syndrome [PDF]

, 2013
Background: SjÖgren's syndrome is an autoimmune syndrome involving the exocrine glands specially the salivary and lacrimal glands leading to xerostomia and xerophtalmia. This paper presents a case with primary SjÖgren's syndrome that severe dental caries
Ahmadi, Elham., Alaeddini, Mojgan., Fallahi, Sasan., Hasani Tabatabaei, Masoomeh.   +3 more
core   +1 more source

Anti-salivary gland protein 1 antibodies in two patients with Sjogren’s syndrome: two case reports [PDF]

, 2014
INTRODUCTION: Current diagnostic criteria for Sjogren’s syndrome developed by the American College of Rheumatology include the presence of antinuclear antibodies, rheumatoid factor, anti-Ro or anti-La autoantibodies.
Julian L Ambrus, Lakshmanan Suresh, Long Shen, Sahana Vishwanath   +3 more
core   +2 more sources