Results 61 to 70 of about 37,519 (224)

Sjögren’s syndrome with rapidly progressive motor neuron disease: a case report

Journal of International Medical Research, 2020
Sjögren’s syndrome is an autoimmune disease that can affect multiple systems. Sjögren’s syndrome with motor neuron disease is rarely reported. Herein, we describe a patient with rapidly progressive motor neuron disease secondary to Sjögren’s syndrome.
Huijia Yang, Xiaozhong Jing, Jinhua Yan, Dihui Ma   +3 more
doaj   +1 more source

Renal Involvement in Primary Sjogren's Syndrome: A Case Series of Three Cases with Various Clinicopathological Presentations

Saudi Journal of Kidney Diseases and Transplantation, 2022
Sjogren's syndrome is a prevalent and underdiagnosed systemic disease that primarily affects epithelial tissue. It may affect renal function, either as an epithelial disease causing tubulointerstitial nephritis (TIN) or as an immune complex-mediated ...
Bhawna Agnani, Ranjana Solanki, Deepika Hemrajani   +2 more
doaj   +1 more source

Histopathology and immunopathology in minor salivary glands of patients with Sjögren's syndrome (SSj) [PDF]

, 2005
Sjögren's syndrome (SSj) is a chronic autoimmune disorder characterized by lymphocytic infiltration of the exocrine glands with concomitant destruction of the glandular tissue, affecting predominantly salivary and lacrimal glands.
Andrade, Luiz Eduardo Coelho, Barcellos, Karin Spat Albino   +1 more
core   +2 more sources

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Clinical characteristics and risk factors of Helicobacter pylori infection‐associated Sjogren's syndrome

Immunity, Inflammation and Disease, 2023
Objective Although infectious pathogens are predominant factors for inducing and maintaining immune system disorders, there exist few reports establishing the significant correlation between Helicobacter pylori (H.
Ye He, Lingzhen Hu, Wei Qiu, Lixia Zhu, Xiaochun Zhu, Mingzhi Hong   +5 more
doaj   +1 more source

Comparison of ESSDAI and ClinESSDAI in potential optimization of trial outcomes in primary Sjögren’s syndrome: examination of data from the UK Primary Sjögren’s Syndrome Registry [PDF]

, 2018
OBJECTIVES: To assess the use of the Clinical EULAR Sjögren’s Syndrome Disease Activity Index (ClinESSDAI), a version of the ESSDAI without the biological domain, for assessing potential eligibility and outcomes for clinical trials in patients with ...
Adrian, J, Alexandre, D, Andrea, R, Annie, C, Benjamin, FA, Bhaskar, D, Bridget, G, Colin, PT, Costantino, P, David, C, David, I, Elizabeth, P, Francesca, B, Ian, G, John, M, Katherine, J, Michele, B, Mohammed, A, Monica, G, Nagui, G, Neil, M, Nurhan, S, Paul, E, Peter, L, Regis, UKPSS, Robert, MJ, Saaeha, R, Simon, BJ, Steven, Y-M, Vadivelu, S, Wan-Fai, N   +30 more
core   +6 more sources

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Rectal mucosal prolapse syndrome as an unusual gastrointestinal manifestation of Sjögren's syndrome: a case report

Journal of Medical Case Reports, 2009
Introduction Rectal mucosal prolapse syndrome, histologically characterized by fibromuscular obliteration in the lamina propria, hyperplastic glands and thickened muscularis mucosa, causes rectal bleeding.
Koga Hideki, Shimizu Kayoko, Tarumi Ken-ichi, Sadahira Yoshito, Matsumoto Takayuki, Iida Mitsuo, Haruma Ken   +6 more
doaj   +1 more source

The TRACTISS protocol: a randomised double blind placebo controlled clinical trial of anti-B-cell therapy in patients with primary Sjögren's Syndrome. [PDF]

, 2014
Background: Primary Sjögren's Syndrome (PSS) mainly affects women (9:1 female:male ratio) and is one of the commonest autoimmune diseases with a prevalence of 0.1 - 0.6% of adult women.
Bombardieri, M, Bowman, S, Brown, S, Busch, R, Dawson, L, Emery, P, Everett, C, Gray, J, Hall, F, Hulme, C, Macleod, I, Navarro Coy, N, Pavitt, S, Pease, C, Pitzalis, C, Poveda-Gallego, A, Price, E, Rauz, S, Reynolds, C, Rout, J, Ruddock, S, Skinner, E, Smith, P, Sutcliffe, N, TRACTISS trial team, Wan-Fai, N, Woods, C   +26 more
core   +3 more sources

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source