Results 71 to 80 of about 37,390 (254)

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

The role of a labial salivary gland biopsy in the diagnostic procedure for Sjögren's syndrome: a study of 94 cases [PDF]

, 2014
Objectives: The purpose of the present study is to examine the role of the outcome of the labial salivary gland biopsy (LSGB) in the diagnostic procedure of patients suspected of suffering from Sjögren's syndrome (SS).
Bloemena, Elisabeth, Santana, Nathalie T.Y., Stein-Callenfels, Dewi van, Tan, Jonathan, Van der Waal, Isaäc, Voskuyl, Alexandre E., Vugt, Richard M. van   +6 more
core   +1 more source

Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects

Animal Models and Experimental Medicine, EarlyView.
Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu, Jiaqi Chen, Zhonghui Li, Jiamin Zhou, Hui Zhang, Yujia Yu, Feng Cheng, Jie Bao, Chunhan Feng, Xiangqu Yu, Zhao Xia, Rao Ding, Xiang Li   +12 more
wiley   +1 more source

Clinical and laboratorial profile and histological features on minor salivary glands from patients under investigation for Sjögren's syndrome [PDF]

, 2014
Diagnosis of Sjögren's syndrome (SS) is complex and the usefulness of labial minor salivary glands biopsy in this process remains controversial. Objectives: to evaluate the clinical and laboratorial profile and histological features on labial minor ...
dos-Santos, Teresa-Cristina-Ribeiro-Bartholomeu, Pereira, Débora-Lima, Pires, Fábio-Ramôa, Vilela, Verônica-Silva   +3 more
core   +1 more source

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

Arthritis &Rheumatology, EarlyView.
Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley   +1 more source

Comparison of ESSDAI and ClinESSDAI in potential optimization of trial outcomes in primary Sjögren’s syndrome: examination of data from the UK Primary Sjögren’s Syndrome Registry [PDF]

, 2018
OBJECTIVES: To assess the use of the Clinical EULAR Sjögren’s Syndrome Disease Activity Index (ClinESSDAI), a version of the ESSDAI without the biological domain, for assessing potential eligibility and outcomes for clinical trials in patients with ...
Adrian, J, Alexandre, D, Andrea, R, Annie, C, Benjamin, FA, Bhaskar, D, Bridget, G, Colin, PT, Costantino, P, David, C, David, I, Elizabeth, P, Francesca, B, Ian, G, John, M, Katherine, J, Michele, B, Mohammed, A, Monica, G, Nagui, G, Neil, M, Nurhan, S, Paul, E, Peter, L, Regis, UKPSS, Robert, MJ, Saaeha, R, Simon, BJ, Steven, Y-M, Vadivelu, S, Wan-Fai, N   +30 more
core   +6 more sources

Long‐Term Outcomes of Reduced‐Intensity Conditioning Hematopoietic Stem Cell Transplantation for Patients With Systemic Sclerosis With Impaired Cardiac Function

Arthritis &Rheumatology, EarlyView.
Objective High‐intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced systemic sclerosis (SSc). The role of reduced‐intensity conditioning (RIC) before AHSCT in this population remains unclear.
Yonatan Lean, Carrie Richardson, Anthony J. Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

Pulmonary manifestations of Sjögren's syndrome

European Respiratory Review, 2016
In 9–20% of cases, Sjögren's syndrome is associated with various respiratory symptoms. The most typical manifestations are chronic interstitial lung disease (ILD) and tracheobronchial disease.
Thomas Flament, Adrien Bigot, Benjamin Chaigne, Helene Henique, Elisabeth Diot, Sylvain Marchand-Adam   +5 more
doaj   +1 more source

Quantitative Assessment of Salivary Gland Parenchymal Vascularization Using Power Doppler Ultrasound and Superb Microvascular Imaging: A Potential Tool in the Diagnosis of Sjögren"s Syndrome

Balkan Medical Journal, 2020
Background: Primary Sjögren’s syndrome is a chronic inflammatory autoimmune disease. Minor salivary gland biopsy is the gold standard for the diagnosis of primary Sjögren’s syndrome.
Fethi Emre Ustabaşıoğlu, Selçuk Korkmaz, Ufuk İlgen, Serdar Solak, Osman Kula, Sezin Turan, Hakan Emmüngil   +6 more
doaj   +1 more source

Genome‐Wide DNA Methylation Patterns in Naive CD4+ T Cells From Patients With Primary Sjögren's Syndrome [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106121/1/art38264 ...
Altorok, Asou, Bave, Bird, Browning, Bruniquel, Clark, Cobb, Coit, Delaleu, Dennis, Emamian, Fava, Fava, Fox, Fu, Gatumu, Gottenberg, Hediger, Hjelmervik, Hu, Huang, Hughes, Jeffries, Kassan, Kassan, Kundu, Mavragani, Morinobu, Murayama, Nikolov, Okuda, Pertovaara, Relton, Rennert, Shen, Shen, Sun, Thabet, Vitali, Ware, Weissman   +41 more
core   +1 more source