Results 121 to 130 of about 1,167,016 (249)

Profiles of peripheral B cell subsets in a cohort of primary Sjögren's syndrome patients and their potential clinical significance

Journal of Dental Sciences
Background/purpose: Primary Sjögren's syndrome is a prototypical autoimmune disease, with B cell dysfunction as a dominant feature. Further insights into distribution of B cell subsets in primary Sjögren's syndrome are urgently required to identify the ...
Yixiao Xing, Boya Li, Pan Wei, Hong Hua
doaj   +1 more source

Charting the course of Sjögren's disease: A historical analysis of scientific progress

European Journal of Oral Sciences, EarlyView.
Abstract Sjögren's disease (SjD) bears the name of the Swedish ophthalmologist Henrik Sjögren. His 1933 doctoral thesis on keratoconjunctivitis sicca ignited interest, yet much remains under debate. SjD is an autoimmune disorder that primarily affects the exocrine glands, particularly the salivary and lacrimal glands, leading to a dryness of the eyes ...
Diego Ustárroz Cantali, Fabiola Reis de Oliveira, Denise Cantarelli Machado, Moisés Evandro Bauer   +3 more
wiley   +1 more source

Relationship Between Perfluoroalkyl Acids in Human Serum and Sjogren’s Syndrome: A Case–Control Study of Populations in Hangzhou, China

Exposure to perfluoroalkyl acids (PFAAs) has been found to elicit a range of detrimental effects on human health. However, limited research has investigated the impact of PFAAs on immunity and immune disorders such as Sjogren’s syndrome, with existing ...
Jing Xue, Chuanbing Fan, Shetuan Hu, Kaizhen Liao, Yun Zhao, Hangbiao Jin, Songzhao Zhang   +6 more
core   +1 more source

Integrating Supragingival Scaling and Biofilm Management Into Breast Cancer Patients' Care

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objective The study was designed as a quasi‐experimental clinical trial to evaluate the impact of chemotherapy on periodontal conditions, haematology and salivary flow in patients with breast cancer and gingivitis, after supragingival scaling.
Kelly R. V. Villafuerte, Francisco J. Candido Dos Reis, Hélio H. A. Carrara, Cristhiam H. Martinez, Daniela B. Palioto   +4 more
wiley   +1 more source

Sjögren's Syndrome With Distal Renal Tubular Acidosis and Hypokalemic Myopathy in Pregnancy: A Rare Case

Clinical Case Reports
Sjogren's syndrome may rarely present with distal renal tubular acidosis (dRTA), causing severe hypokalemia and myopathy. A 27‐year‐old primigravida at 15 weeks gestation presented with progressive proximal weakness and myalgia.
Nabiha Khan, Aasim Ali, Sadia Khan, Uzka Ghayour, Dipesh Kumar Yadav, Armaghana Abdullah   +5 more
doaj   +1 more source

Sjögren’s syndrome: history and challenges in diagnosis

Problemy Pielęgniarstwa
The aim of this study is to provide a comprehensive review and analysis of current diagnostic methods for Sjögren’s syndrome and to highlight the historical progress in diagnosing dry eye syndrome.
Kinga Brzdęk, Szymon Wiśniewski, Olga Domańska, Wiktor Baran, Michał Brzdęk   +4 more
doaj   +1 more source

Scalp Dysesthesia: Emerging Pathophysiologic Insights and Therapeutic Implications

International Journal of Dermatology, EarlyView.
Scalp dysesthesia is a chronic condition diagnosed through exclusion. This scoping review synthesized data from 59 patients to identify recurrent clinical features, comorbidities, and management strategies that may support earlier diagnosis. Emerging patterns suggest that neuronal sensitization may underlie common symptoms.
Aditya K. Gupta, Jaspreet Kaur, Amanda Liddy, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source

Advances in Cytosolic dsRNA Sensing of Viral Infections

Immunology &Cell Biology, EarlyView.
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley   +1 more source

Sjögren’s syndrome and hepatitis C virus infection presenting as hypokalemic quadriparesis: A case report

Journal of International Medical Research
Distal renal tubular acidosis can present with acute-onset quadriparesis caused by severe hypokalemia, and primary Sjögren’s syndrome is a significant potential cause of distal renal tubular acidosis in such patients.
Ashish Joshi, Ujjwol Prasad Risal, Navin Kumar Sah, Bhupendra Shah   +3 more
doaj   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source