Results 91 to 100 of about 6,051,053 (294)

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

The Relatıonshıps Between Some Cephalometrıc Measurements And The Increments In Skeletal Age, Heıght, And Weıght In The Chıldren Aged 10—11 Years

Turkish Journal of Orthodontics, 1989
In this study, the heights and weights of 66 children, 34 females and 32 males, aged 10—11 years were measured, and their hand-wrist and cephalometric head radiographs were taken at the interval of one year. Some angular and linear measurements were made
Abdulvahit Erdem, Ümit Gazilerli
doaj   +1 more source

Skeletal muscle mTORC1 regulates whole-body metabolism [PDF]

, 2015
Skeletal muscle, which represents over 40% of the total body mass, is a dynamic tissue with a key role in the maintenance of metabolic homeostasis. Several lines of evidence indicate that alterations of the normal muscle function, as for example in ...
Ormazabal, Maitea Guridi
core   +1 more source

Regulation of murine skeletal muscle growth by STAT5B is age- and sex-specific.

, 2022
BackgroundSexually dimorphic growth has been attributed to the growth hormone (GH)/insulin-like growth factor 1 (IGF1) axis, particularly GH-induced activation of the intracellular signal transducer and activator of transcription 5B (STAT5B), because ...
Hennebry, Alex S, Conaglen, John V, Elston, Marianne S, McMahon, Chris D, Paul, Ryan G   +4 more
core   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo, Claudia Dosi, Stefano Parravicini, Riccardo Zanin, Marta Cheli, Eleonora Giacopuzzi Grigoli, Amalia Canciello, Francesca Andreetta, Riccardo Masson, Silvia Bonanno, Stefania Marcuzzo, Lorenzo Maggi   +11 more
wiley   +1 more source

Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy

Chaperone-mediated autophagy (CMA) contributes to proteostasis maintenance by selectively degrading a subset of proteins in lysosomes. CMA declines with age in most tissues, including skeletal muscle.
Diaz, Antonio, Ramírez-Pardo, Ignacio, Concepcion, Axel R., D'Alessandro, Angelo, Chavda, Bhakti, Pharaoh, Gavin, D\u2019Alessandro, Angelo, Gazteluiturri, Aiara, Tasset, Inmaculada, Feske, Stefan, Hartnell, Lisa M., Ubaida-Mohien, Ceereena, Hartnell, Lisa, Khawaja, Rabia R., Ferrucci, Luigi, Khawaja, Rabia, Qaisar, Rizwan, Mu\uf1oz-C\ue1noves, Pura, Lindenau, Kristen, Santiago-Fernández, Olaya, Van Remmen, Holly, Macho González, Adrián, Muñoz-Cánoves, Pura, Reisz, Julie A., Kaushik, Susmita, Banskota, Nirad, Kinter, Michael, Santiago-Fern\ue1ndez, Olaya, Macho-Gonz\ue1lez, Adri\ue1n, Concepcion, Axel R, Coletto, Luisa, Ahn, Bumsoo, Donega, Stefano, Ram\uedrez-Pardo, Ignacio, Cuervo, Ana Maria   +34 more
core   +1 more source

The relationship of mandibular radiomorphometric indices to skeletal age, chronological age and skeletal malocclusion type [PDF]

, 2017
The present study was performed with the following aims: (1) to assess the relationship between skeletal age, measured using the cervical vertebral maturity (CVM) method, and chronological age; (2) to determine the correlation of skeletal and ...
M Tofangchiha, Tayebi, Ali, A Tayebi, MA Fard, Gosili, Armin, A. Gosili, Fard, Mahsa Arian, Tofangchiha, Maryam   +7 more
core   +1 more source

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source