Advanced Science, EarlyView.A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen +5 more
wiley +1 more source
AI-Assisted Dynamic Postural Control Screening to Improve Functional Mobility in Older Adult Populations: Quasi-Experimental Study. [PDF]
JMIR AgingLin KC, Wai RJ, Chang Chien HY.
europepmc +1 more source
Quantum‐Like Dynamics in Whole‐Brain Models of the Human Connectome
Advanced Science, EarlyView.Quantum‐like dynamics in the human brain. The level of quantum‐like behavior in a non‐quantum system of coupled oscillators is regulated by the spectral gap of the coupling graph. Whole‐brain modelling using QL fits the empirical data significantly better and has a lower model‐derived energy cost than the non‐QL model.
Gustavo Deco +5 more
wiley +1 more source
The Myokinib monograph: operationalizing oncology's highest-value systemic therapeutic. [PDF]
OncologistAryal B.
europepmc +1 more source
Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy
Advanced Science, EarlyView.This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao +5 more
wiley +1 more source
BCST-GCN: a skeleton-based spatiotemporal graph convolutional network with bidirectional cross-attention for pig behavior recognition. [PDF]
Front Vet SciChai H, Zhan W, Su J.
europepmc +1 more source
Advanced Science, EarlyView.Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu +16 more
wiley +1 more source
A Computational Framework for Simulating Patient-Specific TMJ Biomechanics Using a Combined Multibody Dynamics and Finite Element Approach. [PDF]
Ann Biomed EngAhmadi F +14 more
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT Translating dynamic liquid‐liquid phase separation into robust solid‐state architectures remains a challenge in materials engineering. Here, we report a composition‐driven interfacial assembly strategy that couples supramolecular coacervation with metal‐phenolic coordination to engineer tunable fungicide carriers.
Rui Zhang +7 more
wiley +1 more source
Canine Adipose MSC-Derived Exosomes Ameliorate Skeletal Muscle Injury in Mice. [PDF]
Animals (Basel)Gao J, Li Y, Zhong Y.
europepmc +1 more source