Results 41 to 50 of about 9,993 (262)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Present Researching Approaches and Future Prospects for Treatment of Cardiac Diseases - Integrative Medicine

World Journal of Traditional Chinese Medicine, 2015
The pathogenesis of cardiac diseases is very complex and involved in many gene transcription and protein expression. How to effectively treat the diseases has become the hotspot of modern medicine.
Yan Feng, Hao Xu, Yi-Xin Wang, Li-Ping Ma, Da-Zhuo Shi   +4 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

An algorithmic approach to detect generalization in sketch maps from sketch map alignment

PLOS ONE
Sketch maps are valuable tools used across various disciplines including spatial cognition, environmental psychology, and spatial reasoning. A common approach to evaluate sketch maps in research is to align and compare them with metric maps. However, sketch maps are highly abstract and contain generalized information causing difficulty in their ...
Charu Manivannan, Jakub Krukar, Angela Schwering   +2 more
openaire   +3 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Integrating hybrid priors for face photo-sketch synthesis

Journal of Information and Intelligence
Benefiting from the advancement of deep learning techniques, face photo-sketch synthesis has witnessed significant progress in recent years. Cutting-edge methods typically treat this task as an image-to-image translation problem and train a conditional ...
Kun Cheng, Mingrui Zhu, Nannan Wang, Xinbo Gao   +3 more
doaj   +1 more source

Innovative Remote Sensing Methodologies for Kenyan Land Tenure Mapping

Remote Sensing, 2020
There exists a demand for effective land administration systems that can support the protection of unrecorded land rights, thereby assisting to reduce poverty and support national development—in alignment with target 1.4 of UN Sustainable ...
Mila Koeva, Claudia Stöcker, Sophie Crommelinck, Serene Ho, Malumbo Chipofya, Jan Sahib, Rohan Bennett, Jaap Zevenbergen, George Vosselman, Christiaan Lemmen, Joep Crompvoets, Ine Buntinx, Gordon Wayumba, Robert Wayumba, Peter Ochieng Odwe, George Ted Osewe, Beatrice Chika, Valerie Pattyn   +17 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source