Results 81 to 90 of about 2,541,137 (309)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Pix3D: Dataset and Methods for Single-Image 3D Shape Modeling

open access: yes, 2018
We study 3D shape modeling from a single image and make contributions to it in three aspects. First, we present Pix3D, a large-scale benchmark of diverse image-shape pairs with pixel-level 2D-3D alignment.
Freeman, William T.   +7 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Nonclassical stochastic flows and continuous products

open access: yes, 2004
Contrary to the classical wisdom, processes with independent values (defined properly) are much more diverse than white noise combined with Poisson point processes, and product systems are much more diverse than Fock spaces.
Boris Tsirelson   +1 more
core   +3 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

A Cube Analytical Mining Framework for Stream Data

open access: yesDianxin kexue, 2014
Stream data has been one of the most significant data format recently. OLAM(online analytical mining) operation could provide multi-level data views for analysts.
Canghong Jin   +3 more
doaj   +2 more sources

A somewhat gentle introduction to differential graded commutative algebra

open access: yes, 2013
Differential graded (DG) commutative algebra provides powerful techniques for proving theorems about modules over commutative rings. These notes are a somewhat colloquial introduction to these techniques.
Beck, Kristen A., Sather-Wagstaff, Sean
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

MILITARY SKETCHING AND MAP READING [PDF]

open access: yesJournal of the American Medical Association, 1917
The ability to read maps is an absolutely essential qualification of a medical officer. Instructions conveyed to him in the field often contain references to maps. If he is unable to understand these references his efficiency is greatly impaired. Then, too, the question of shelter and cover from fire at distant points at which it might be desirable to ...
openaire   +1 more source

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