Results 91 to 100 of about 564,399 (275)

Sex and/or Gender? Some Neuroscientific Approache

open access: yesHumana.Mente: Journal of Philosophical Studies, 2012
Traditionally, Gender Studies differentiates between the term “sex”, indicating sex differences from the biological point of view, and the term “gender”, indicating that sex differences are social and cultural constructions.
Valentina Chizzola
doaj  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Insights into designers’ sketching: a study of predictors of sketching behavior in design

open access: yesDesign Science
Abstract Freehand sketching meets a vital need in design for fluid, fast and flexible visual representations that designers build off of and learn from. Sketching more frequently during the design process correlates with positive design outcomes. Engineering designers receive minimal training on freehand sketching, and engineering students do not ...
Morgan B. Weaver   +2 more
openaire   +1 more source

Attribute-Guided Sketch Generation

open access: yes, 2019
Facial attributes are important since they provide a detailed description and determine the visual appearance of human faces. In this paper, we aim at converting a face image to a sketch while simultaneously generating facial attributes.
Chen, Xinya   +6 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

50 years of Russian studies in Tromsø

open access: yesPoljarnyj Vestnik: Norwegian Journal of Slavic Studies
In the fall semester of 1974, Associate Professor Ingvild Broch received the first four students of Russian at the University of Tromsø. In November 2024, we celebrated the first half century of Russian studies at our university, which is now known as ...
Tore Nesset
doaj   +1 more source

Physical activity in health promotion: a evaluation of the guidelines

open access: yesSemina: Ciências Biológicas e da Saúde, 2015
Regular physical activity (PA) promotes health benefits over time. Numerous organizations produce guidelines to guide public administrators, health professionals and the public in general to the practice of PA.
Dartel Ferrari de Lima   +1 more
doaj   +1 more source

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