Results 71 to 80 of about 42,550 (261)

Sex and/or Gender? Some Neuroscientific Approache

open access: yesHumana.Mente: Journal of Philosophical Studies, 2012
Traditionally, Gender Studies differentiates between the term “sex”, indicating sex differences from the biological point of view, and the term “gender”, indicating that sex differences are social and cultural constructions.
Valentina Chizzola
doaj  

Estimating similarity and distance using FracMinHash

open access: yesAlgorithms for Molecular Biology
Motivation The increasing number and volume of genomic and metagenomic data necessitates scalable and robust computational models for precise analysis.
Mahmudur Rahman Hera, David Koslicki
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Hierarchical Schema Representation for Text-to-SQL Parsing With Decomposing Decoding

open access: yesIEEE Access, 2019
Most of existing studies on parsing natural language (NL) for constructing structured query language (SQL) do not consider the complex structure of database schema and the gap between NL and SQL query.
Meina Song, Zecheng Zhan, Haihong E.
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

50 years of Russian studies in Tromsø

open access: yesPoljarnyj Vestnik: Norwegian Journal of Slavic Studies
In the fall semester of 1974, Associate Professor Ingvild Broch received the first four students of Russian at the University of Tromsø. In November 2024, we celebrated the first half century of Russian studies at our university, which is now known as ...
Tore Nesset
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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