Results 61 to 70 of about 14,528,314 (288)
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Insights into designers’ sketching: a study of predictors of sketching behavior in design
Design ScienceAbstract Freehand sketching meets a vital need in design for fluid, fast and flexible visual representations that designers build off of and learn from. Sketching more frequently during the design process correlates with positive design outcomes. Engineering designers receive minimal training on freehand sketching, and engineering students do not ...
Morgan B. Weaver +2 more
openaire +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Revisiting Caffeine Biosynthesis – Speculations about the Proximate Source of its Purine Ring
Natural Product Communications, 2015 The prevailing hypothesis of caffeine biosynthesis starting from xanthosine was combined with Kremers’ speculation on NAD as a biochemical precursor of caffeine and trigonelline in coffee.
Thomas W. Baumann
doaj +1 more source
The Integrity of Intentionality: Sketch for a Phenomenological Study [PDF]
, 2016 In this chapter, Matthew Ratcliffe addresses the question ‘what constitutes the sense of being in one kind of intentional state, rather than another?’ In other words, in virtue of what do we experience ourselves as currently perceiving that p rather than, for instance, currently imagining that p?
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Humanitarian and Conflict Oriented Early Warning: A Historical Background Sketch
Refuge, 1997 This article provides a brief and informative overview of the overall development of early warning over past years. It also includes references to the author's own involvement in the field as Director of the Centre for Refugee Studies and, later ...
Howard Adelman
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source