Results 61 to 70 of about 564,148 (293)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Why Should We Talk About Culture, When We Want to Understand ‘Surveillance’?
On_Culture, 2018 Why should we talk about culture, when we want to understand ‘surveillance’? The following is a brief sketch towards an answer to this question. It has two parts: first, it presents and discusses how the term ‘culture’ is used within Surveillance Studies,
Dietmar Kammerer
doaj +3 more sources
Anthony D. Smith (1939-2016) jako socjolog narodu: szkic do portretu intelektualnego
Sprawy Narodowościowe. Seria nowa, 2019 Anthony D. Smith (1939-2016) as a sociologist of the nation: a sketch to an intellectual portrait The aim of this article is to present a sketch of the intellectual biography of Anthony D.
Jacek Poniedzialek
doaj +1 more source
ANDHARUPA: Jurnal Desain Komunikasi Visual & Multimedia, 2023 Abstrak Wisata heritage merupakan salah satu jenis wisata yang mengalami pertumbuhan di beberapa negara yang memiliki keragaman dan keunikan warisan budaya. Popularitas wisata heritage memberikan kontribusi kepada peningkatan citra kota.
Kunkun Kurniawan +2 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Phenomenology of Philosophy of Science: OPERA data [PDF]
, 2012 I observe that, as the physics side of the OPERA-anomaly story is apparently unfolding, there can still be motivation for philosophy of science to analyze the six months of madness physicists spent chasing the dream of a new fundamental-physics ...
Amelino-Camelia, Giovanni
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source