Results 71 to 80 of about 564,148 (293)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Davidson on the impossibility of thought without language: comments on Diana I. Pérez

Principia: An International Journal of Epistemology, 2012
Diana Pérez (2005) criticizes Davidson’s argument for the thesis that there is no thought without language, and offers an alternative defense of that thesis on the basis of empirical studies on developmental psychology.
Marcelo Fischborn
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Application of the Neutrosophic Fuzzy Sets in Profession Determination [PDF]

Neutrosophic Sets and Systems
We present several operations, such as algebraic sum, algebraic product, and arithmetic mean, over the neutrosophic sets extended with moment in time and sketch numbers.
K. Rajesh, S. Moorthy, A. Jeeva, D. Moganraj   +3 more
doaj   +1 more source

The Digital Restoration of Da Vinci's Sketches

, 2009
A sketch, found in one of Leonardo da Vinci's notebooks and covered by the written notes of this genius, has been recently restored. The restoration reveals a possible self-portrait of the artist, drawn when he was young.
Sparavigna, Amelia
core  

On Holomorphic Factorization in Asymptotically AdS 3D Gravity

, 2002
This paper studies aspects of ``holography'' for Euclidean signature pure gravity on asymptotically AdS 3-manifolds. This theory can be described as SL(2,C) CS theory.
Aharony O, Aldrovandi E, Aminneborg S, Arcioni G, Ashtekar A, Ashtekar A, Ashtekar A, Balasubramanian V, Banados M, Banados M, Brill D, Brown J D, Carlip S, Chekhov L, Coussaert O, Fefferman C, Fock V V, Ford L, Freidel L, Gawedzki K, Goldman W, Govindarajan T R, Graham C R, Gunning R C, Gunning R C, Kashaev R M, Kashaev R M, Kawai S, Kirill Krasnov, Krasnov K, Krasnov K, Maldacena J, Matschull H J, Matsuzaki K, Moncrief V, Polyakov A M, Ponsot B, Rooman M, Rooman M, Skenderis K, Takhtajan L, Teschner J, Teschner J, Thurston W, Verlinde H, Witten E, Witten E, Witten E, Witten E   +48 more
core   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Sketching Theoretical Frameworks for American Studies

VNU Journal of Science: Education Research, 2018
This paper analyzes briefly the theoretical frameworks developed by major thinkers in American Studies (Alexis de Toccqueville, Israel Zangwill, Max Weber, Frederick Jackson Turner) and proposes a new theoretical framework that approaches to the USA as the biggest, earliest, and the most successful Special Free Economic Zone in the history. ...
openaire   +2 more sources

A Comparative Study on Face Sketch Synthesis

IEEE Access, 2018
The purpose of face sketch synthesis technique is to generate a sketch from an input face image given a set of face sketch-photo images as the training set. Since face sketch synthesis is attracting huge attentions, an experimental study to existing methods is nontrivial.
Adeel Akram, Nannan Wang, Jie Li, Xinbo Gao   +3 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source