Advanced Science, EarlyView.Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh +22 more
wiley +1 more source
Complete Mitochondrial Genome and Phylogenetic Analysis of the Chungtien Schizothoracin (<i>Ptychobarbus chungtienensis</i>). [PDF]
Curr Issues Mol BiolQian Y +6 more
europepmc +1 more source
Advanced Science, EarlyView.Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen +6 more
wiley +1 more source
Non-IID and aware federated intrusion detection with PBFT with secured model aggregation for multi institutional healthcare internet of things networks. [PDF]
Sci RepSengan S, Shieh CS.
europepmc +1 more source
CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction
Advanced Science, EarlyView.CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su +5 more
wiley +1 more source
Complete Mitochondrial Genome of the Endemic Loach <i>Leptobotia tchangi</i> and Its Phylogenetic Placement Within Botiidae. [PDF]
Genes (Basel)Hu Y, Duan G, Zhou H, Liu A, Wang H.
europepmc +1 more source
Advanced Science, EarlyView.This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang +10 more
wiley +1 more source
BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer
Advanced Science, EarlyView.BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu +12 more
wiley +1 more source
New mitogenomic evidence for the phylogeny of Siphonaptera: insights from <i>Callopsylla dolabris</i> and <i>Oropsylla silantiewi</i>. [PDF]
Front Vet SciZhang W +8 more
europepmc +1 more source
Sheet‐Size‐Dependent Mosaicity of 2D Phyllosilicate Membranes
Advanced Science, EarlyView.This study explores how the size of 2D vermiculite sheets affects the structure of laminar membranes. High‐resolution x‐ray diffraction reveals how sheet size governs structural disorder and crystallinity. These changes directly impact ion permeability.
Min A Kim +6 more
wiley +1 more source