Results 171 to 180 of about 6,790,902 (292)
Advanced Science, EarlyView.Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao +15 more
wiley +1 more source
Evaluating Scoring Mechanisms for Measuring the Stroop Effect in Individuals With Down Syndrome. [PDF]
J Intellect Disabil ResDenne E +4 more
europepmc +1 more source
Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis
Advanced Science, EarlyView.CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan +13 more
wiley +1 more source
Mapping of quantitative trait loci using the skew-normal distribution. [PDF]
J Zhejiang Univ Sci B, 2007 Fernandes E +2 more
europepmc +1 more source
The Univariate Skew-Normal Distribution
The Journal of Applied Science, 2021 openaire +2 more sources
A Modified Two-Piece Skew Normal Distribution: Properties and Applications
, 2016 A new class of two-piece skew normal distribution is introduced here as a generalization of the two-piece skew normal distribution of Kumar and Anusree (Statistics, 2013) and the generalized skew normal distribution of Gupta and Gupta (Test, 2004).
Kumar, C. Satheesh, Anusree, M. R.
core +2 more sources
Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target
Advanced Science, EarlyView.Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen +12 more
wiley +1 more source
A metric for quantifying adaptation to successive disruptions. [PDF]
Sci Repvan Steijn F +3 more
europepmc +1 more source
A new class of Skew-Normal-Cauchy Distribution
In this paper we study a new class of skew-Cauchy distributions inspired on the family extended two-piece skew normal distribution. The new family of distributions encompasses three well known families of distributions, the normal, the two-piece skew ...
Bolfarine, Heleno +3 more
core
Advanced Science, EarlyView.Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu +18 more
wiley +1 more source