Results 191 to 200 of about 17,511,424 (267)

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Psychometric properties and symptom profiles of the PHQ-9 and DASS-21 among medical and non-medical university students: a cross-sectional study in Pakistan. [PDF]

BMC Psychol
Asghar T, Hassan A, Sahar I, Tahir M, Shahid B, Komal K.   +5 more
europepmc   +1 more source

Correction to: S2LU: An Activation Function Based on Skew Student’s t-distribution for Improved Neural Network Performance

Neural Computing and Applications
Özcan Küçükalİ, M. Hakan Bozkurt, Esma Ulutaş, Işılay Bozkurt   +3 more
openaire   +1 more source

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

Medical student syndrome among medical and nonmedical students at Sultan Qaboos University: A comparative study of health anxiety. [PDF]

J Educ Health Promot
Al Lawati A, Alhadithy Z, Al Abri GN, Al Lawati GS, Al Azri MI, Al-Mahrouqi T, Al-Mufargi Y, Al Sinawi H.   +7 more
europepmc   +1 more source

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

Advanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source

Motivation for physical activity participation and mindful eating in university students: a cross-sectional study using variable-centered regression and latent profile analysis. [PDF]

Front Psychol
Orhan BE, Alkasasbeh WJ, Solak N, Amawi AT.   +3 more
europepmc   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

WALANT Versus Sedation for Hand Trauma: A Comparative Cost Analysis in a Portuguese Public Hospital. [PDF]

Plast Reconstr Surg Glob Open
Santos Lopes C, Lalonde DH, Ribak S, Almeida A, Ferreira D, Marques-Gomes J.   +5 more
europepmc   +1 more source

Learning Work Function via Implicit Reasoning on Electrostatic Potential Landscapes

Advanced Science, EarlyView.
StructPot‐CLR establishes a cross‐modal contrastive learning framework that aligns the crystal structures of 2D materials with plane‐averaged electrostatic potential landscapes for physically informed work‐function prediction. The model achieves an MAE of 0.265 eV and an R2 of 0.902 on the held‐out test set while accurately preserving key morphological
Haoyu Wan, Yue Wu, Tianhao Su, Deng Pan
wiley   +1 more source