Results 161 to 170 of about 2,203,706 (318)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Article Commentary: Rethinking Breast Self-Examinations: Are We Asking the Right Questions?
Steven J. Danish +2 more
doaj +1 more source
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Title from coverAvailable from British Library Document Supply Centre- DSC:m03/12589 / BLDSC - British Library Document Supply CentreSIGLEGBUnited ...
e-skills UK (United Kingdom)
core
Educating Early Adolescents for a Sustainable Future With Digital Civic Learning: Moral Self-Concept as a Developmental Catalyst Linking Civic Competencies and Civic Purpose. [PDF]
Kim S, Lin TJ, Glassman M, Anderman E.
europepmc +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Bidirectional Relations Between Spatial and Mathematics Skills in Elementary School Children: The Role of Domain-Specific Anxieties. [PDF]
Geer EA, Barroso C, Ganley CM.
europepmc +1 more source
Skills in Flux - Challenges in AI-based Skills Management and Skills Profiles.
The changing world of work, driven by automation and digital tech-nologies, requires a workforce that continuously adapts its skills in order to be competitive and employable. This dynamic environment has fueled the demand for advanced skills management, with artificial intelligence (AI) playing a critical role in measuring and supporting individual ...
Leonie Rebecca Freise +2 more
openaire +2 more sources
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source

