Results 111 to 120 of about 167,860,391 (261)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Skills in Higher Education

open access: yes, 2011
This unit contains a PowerPoint presentation about assessing key skills, with explanatory notes, and an audio recording of the two authors talking through the presentation.
Dr Rosalind Duhs   +3 more
core  

MANAGING THE TRANSLATION OF ECONOMIC TEXTS [PDF]

open access: yesAnnals of the University of Oradea: Economic Science, 2012
Theoretically, translation may pass as science; practically, it seems closer to art. Translation is a challenging activity requiring a set of abilities and posing few difficulties that appear during the translation process.
Pop Anamaria Mirabela, Sim Monica Ariana
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Accomplishment in the multitude of counsellors: Peer feedback in translation training

open access: yesTranslation and Interpreting : the International Journal of Translation and Interpreting Research, 2013
The study probes into translation students’ perception of the value of online peer feedback in improving translation skills. Students enrolled in a translation degree in Australia translated a 250-word text on two separate occasions.
Kenny Wang, Chong Han
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Participation and Activity Inventory for Children and Youth (PAI-CY): Translation and Cultural Adaptation to European Portuguese

open access: yesBrain Sciences
Introduction: Visual skills have a significant impact on an infant’s development and participation. In Portugal, although the public health system is organized to support citizens with visual impairment, it lacks translated and culturally adapted ...
Ana Isabel Ferreira   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Audiovisual Translation and Language Teaching: A Proposal on How to Use Respeaking to Improve Oral Skills

open access: yes
Audiovisual Translation (AVT) and foreign language (FL) learning have converged in recent decades to be an effective combination to improve language skills. Respeaking is one of the few modalities that involves oral practice, since it combines shadowing –
Belenguer Cortés, Luz
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

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