Results 141 to 150 of about 167,860,391 (261)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Turkish cultural adaptation and psychometric evaluation of the children activity scales-parent and teacher forms (ChAS-P/T). [PDF]

Front Pediatr
Demirbas D, Cebi M, May-Benson TA, Balikci A.   +3 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A CREATE-Based Educational Intervention to Improve Evidence-Based Practice Competencies in a Low-Income Country: A Feasibility Pilot Study. [PDF]

Healthcare (Basel)
Marcomini I, Buzzi F, Poliani A, Chiodi Daelli F, Ciceri F, Naranjo Alcaide JC, Omer HIMA, Rosa D, Villa G, Zanuso R, Marhoom M, Manara DF.   +11 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Implementation and evaluation of a technical support center for the Research to Enhance the Adaptation and Implementation of Health Systems Guidelines in LMICs [RAISE] initiative. [PDF]

Health Res Policy Syst
Fahim C, Pratt J, Purewal A, Marsot-Shiffman L, de Launay KQ, Baddeliyanage R, Davenport-Huyer L, Yangchen S, Gebregiorgis AH, Wiysonge CS, Tricco AC, Puchalski-Ritchie L, Pham B, Tuncalp O, Langlois EV, Marten R, Straus SE.   +16 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Developing a one-shot medical Spanish module for medical students: an open educational resource approach. [PDF]

Front Med (Lausanne)
McCarroll J.
europepmc   +1 more source

ENHANCING PROBLEM-SOLVING SKILLS IN MATHEMATICS AMONG GRADE 4 LEARNERS: IMPLEMENTING THE A.C.T.S (ANALYZE, CLUE HUNT, TRANSLATE, AND SOLVE) STRATEGY WITH INTERACTIVE ACTIVITIES

International Journal of Research Publications
Jenny D. Martinez, Rutchell S. Obuta, Kristy Jane R. Muegna, PhD, Deveyvon L. Espinosa, PhD, Leilah V. Gonzales   +4 more
openaire   +1 more source